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| 001 | 272495 | ||
| 005 | 20241001164214.0 | ||
| 024 | 7 | _ | |a 10.1016/j.jagp.2024.05.006 |2 doi |
| 024 | 7 | _ | |a pmid:38824050 |2 pmid |
| 024 | 7 | _ | |a 1064-7481 |2 ISSN |
| 024 | 7 | _ | |a 1545-7214 |2 ISSN |
| 037 | _ | _ | |a DZNE-2024-01171 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Müller, Julia |b 0 |
| 245 | _ | _ | |a Differential Psychological Treatment Effects in Patients With Late-Life Depression and a History of Childhood Maltreatment. |
| 260 | _ | _ | |c 2024 |b Ovid |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1727774207_10917 |2 PUB:(DE-HGF) |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a This is the first interventional study to assess the impact of childhood maltreatment (CM) on psychological treatment outcomes in patients with late-life depression (LLD).This is a secondary analysis of a multicenter, randomized controlled trial with 251 participants aged ≥60 years with moderate to severe depression. Participants were randomly assigned to cognitive behavioral therapy for late life depression (LLD-CBT) or to a supportive intervention (SUI). Treatment outcomes were measured by changes in the Geriatric Depression Scale (GDS).In the intention-to-treat sample (n = 229), both LLD-CBT (n = 115) and SUI (n = 114) significantly reduced depressive symptoms in patients with CM, with large effects at post-treatment (d = 0.95 [95% CI: 0.65 to 1.25] in LLD-CBT; d = 0.82 [95% CI: 0.52 to 1.12] in SUI). A significant treatment group*CM interaction (F(1,201.31) = 4.71; p = .031) indicated greater depressive symptom reduction in LLD-CBT compared to SUI at week 5 and post-treatment for patients without CM, but not at 6-month follow-up. Across both treatments, higher severity of the CM subtype 'physical neglect' was associated with a smaller depressive symptom reduction (F(1,207.16) = 5.37; p = .021).Specific and non-specific psychotherapy effectively reduced depressive symptoms in older individuals with depression and early trauma. For patients without early trauma, LLD-CBT may be preferable over SUI. Considering early trauma subtypes may contribute to develop personalized treatment approaches. |
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| 650 | _ | 7 | |a childhood maltreatment |2 Other |
| 650 | _ | 7 | |a cognitive behavioral therapy |2 Other |
| 650 | _ | 7 | |a early trauma |2 Other |
| 650 | _ | 7 | |a late-life depression |2 Other |
| 650 | _ | 7 | |a non-specific supportive intervention |2 Other |
| 650 | _ | 7 | |a older age |2 Other |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Male |2 MeSH |
| 650 | _ | 2 | |a Female |2 MeSH |
| 650 | _ | 2 | |a Aged |2 MeSH |
| 650 | _ | 2 | |a Cognitive Behavioral Therapy: methods |2 MeSH |
| 650 | _ | 2 | |a Middle Aged |2 MeSH |
| 650 | _ | 2 | |a Depression: therapy |2 MeSH |
| 650 | _ | 2 | |a Treatment Outcome |2 MeSH |
| 650 | _ | 2 | |a Adult Survivors of Child Abuse: psychology |2 MeSH |
| 650 | _ | 2 | |a Child Abuse: psychology |2 MeSH |
| 650 | _ | 2 | |a Aged, 80 and over |2 MeSH |
| 700 | 1 | _ | |a Elsaesser, Moritz |b 1 |
| 700 | 1 | _ | |a Müller, Wiebke |b 2 |
| 700 | 1 | _ | |a Hellmich, Martin |b 3 |
| 700 | 1 | _ | |a Hammen, Magdalena |b 4 |
| 700 | 1 | _ | |a Zehender, Nadine |b 5 |
| 700 | 1 | _ | |a Riedel-Heller, Steffi |b 6 |
| 700 | 1 | _ | |a Bewernick, Bettina H |b 7 |
| 700 | 1 | _ | |a Wagner, Michael |0 P:(DE-2719)2000057 |b 8 |u dzne |
| 700 | 1 | _ | |a Frölich, Lutz |b 9 |
| 700 | 1 | _ | |a Peters, Oliver |0 P:(DE-2719)2811024 |b 10 |u dzne |
| 700 | 1 | _ | |a Dafsari, Forugh S |b 11 |
| 700 | 1 | _ | |a Domschke, Katharina |b 12 |
| 700 | 1 | _ | |a Jessen, Frank |0 P:(DE-2719)2000032 |b 13 |u dzne |
| 700 | 1 | _ | |a Hautzinger, Martin |b 14 |
| 700 | 1 | _ | |a Schramm, Elisabeth |b 15 |
| 773 | _ | _ | |a 10.1016/j.jagp.2024.05.006 |g Vol. 32, no. 11, p. 1325 - 1336 |0 PERI:(DE-600)1474415-6 |n 11 |p 1325 - 1336 |t American journal of geriatric psychiatry |v 32 |y 2024 |x 1064-7481 |
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