000272966 001__ 272966
000272966 005__ 20241128165021.0
000272966 0247_ $$2doi$$a10.5281/ZENODO.11242230
000272966 0247_ $$2doi$$a10.5281/zenodo.11242230
000272966 037__ $$aDZNE-2024-01345
000272966 041__ $$aEnglish
000272966 1001_ $$0P:(DE-2719)2811291$$aGloeckner, Christian Johannes$$b0
000272966 245__ $$aDataset: AlphaFold3 model of G nucleotide-bound LRRK2 phospho-T1343, v1
000272966 260__ $$bZenodo$$c2024
000272966 3367_ $$2BibTeX$$aMISC
000272966 3367_ $$0PUB:(DE-HGF)32$$2PUB:(DE-HGF)$$aDataset$$bdataset$$mdataset$$s1732805994_2420
000272966 3367_ $$026$$2EndNote$$aChart or Table
000272966 3367_ $$2DataCite$$aDataset
000272966 3367_ $$2ORCID$$aDATA_SET
000272966 3367_ $$2DINI$$aResearchData
000272966 520__ $$aAlphaFold3 model of LRRK2-pT1343 either bound to GDP/Mg or GTP/Mg. Using AlphaFold3 (Abramson et al., 2024), we modeled and compared the GDP vs the GTP-state of phospho-T1343 LRRK2. Interestingly, the AlphaFold3 model suggests, that the phosphate group of the pT1343 residue is orientated inwards thereby substituting the gamma phosphate of the GTP in the GDP-bound state of LRRK2. This finding is in well agreement with MD simulations published recently (Stormer et al., 2023).
000272966 536__ $$0G:(DE-HGF)POF4-352$$a352 - Disease Mechanisms (POF4-352)$$cPOF4-352$$fPOF IV$$x0
000272966 588__ $$aDataset connected to DataCite
000272966 650_7 $$2Other$$astructural modeling
000272966 650_7 $$2Other$$aLRRK2
000272966 773__ $$a10.5281/zenodo.11242230
000272966 7870_ $$0DZNE-2024-01346$$aGloeckner, Christian Johannes$$dZenodo, 2024$$iRelatedTo$$r$$tDataset: Supplemental data for 'Intramolecular feedback regulation of the LRRK2 Roc G domain by a LRRK2 kinase dependent mechanism' (Gilsbach et al., eLife 2024, doi:10.7554/eLife.91083), v2
000272966 909CO $$ooai:pub.dzne.de:272966$$pVDB
000272966 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811291$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE
000272966 9131_ $$0G:(DE-HGF)POF4-352$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vDisease Mechanisms$$x0
000272966 9141_ $$y2024
000272966 9201_ $$0I:(DE-2719)1210007$$kAG Gloeckner$$lFunctional Neuroproteomics and Translational Biomarkers in Neurodegenerative Diseases$$x0
000272966 980__ $$adataset
000272966 980__ $$aVDB
000272966 980__ $$aI:(DE-2719)1210007
000272966 980__ $$aUNRESTRICTED