Dataset

DZNE-2024-01345

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Dataset: AlphaFold3 model of G nucleotide-bound LRRK2 phospho-T1343, v1

Gloeckner, C. J.DZNE*

2024
Zenodo

This record in other databases:

Please use a persistent id in citations: doi:10.5281/ZENODO.11242230  doi:10.5281/zenodo.11242230

Abstract: AlphaFold3 model of LRRK2-pT1343 either bound to GDP/Mg or GTP/Mg. Using AlphaFold3 (Abramson et al., 2024), we modeled and compared the GDP vs the GTP-state of phospho-T1343 LRRK2. Interestingly, the AlphaFold3 model suggests, that the phosphate group of the pT1343 residue is orientated inwards thereby substituting the gamma phosphate of the GTP in the GDP-bound state of LRRK2. This finding is in well agreement with MD simulations published recently (Stormer et al., 2023).

Keyword(s): structural modeling ; LRRK2

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Contributing Institute(s):

1. Functional Neuroproteomics and Translational Biomarkers in Neurodegenerative Diseases (AG Gloeckner)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Appears in the scientific report 2024

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Linked articles:

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Dataset Gloeckner, C. J.DZNE*
Dataset: Supplemental data for 'Intramolecular feedback regulation of the LRRK2 Roc G domain by a LRRK2 kinase dependent mechanism' (Gilsbach et al., eLife 2024, doi:10.7554/eLife.91083), v2
Zenodo (2024) [10.5281/zenodo.13837193]2024 BibTeX | EndNote: XML, Text | RIS

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