TY  - CHART
AU  - Gloeckner, Christian Johannes
TI  - Dataset: AlphaFold3 model of G nucleotide-bound LRRK2 phospho-T1343, v1
PB  - Zenodo
M1  - DZNE-2024-01345
PY  - 2024
AB  - AlphaFold3 model of LRRK2-pT1343 either bound to GDP/Mg or GTP/Mg. Using AlphaFold3 (Abramson et al., 2024), we modeled and compared the GDP vs the GTP-state of phospho-T1343 LRRK2. Interestingly, the AlphaFold3 model suggests, that the phosphate group of the pT1343 residue is orientated inwards thereby substituting the gamma phosphate of the GTP in the GDP-bound state of LRRK2. This finding is in well agreement with MD simulations published recently (Stormer et al., 2023).
KW  - structural modeling (Other)
KW  - LRRK2 (Other)
LB  - PUB:(DE-HGF)32
DO  - DOI:10.5281/zenodo.11242230
UR  - https://pub.dzne.de/record/272966
ER  -