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| 001 | 272966 | ||
| 005 | 20241128165021.0 | ||
| 024 | 7 | _ | |a 10.5281/ZENODO.11242230 |2 doi |
| 024 | 7 | _ | |a 10.5281/zenodo.11242230 |2 doi |
| 037 | _ | _ | |a DZNE-2024-01345 |
| 041 | _ | _ | |a English |
| 100 | 1 | _ | |a Gloeckner, Christian Johannes |0 P:(DE-2719)2811291 |b 0 |
| 245 | _ | _ | |a Dataset: AlphaFold3 model of G nucleotide-bound LRRK2 phospho-T1343, v1 |
| 260 | _ | _ | |c 2024 |b Zenodo |
| 336 | 7 | _ | |a MISC |2 BibTeX |
| 336 | 7 | _ | |a Dataset |b dataset |m dataset |0 PUB:(DE-HGF)32 |s 1732805994_2420 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a Chart or Table |0 26 |2 EndNote |
| 336 | 7 | _ | |a Dataset |2 DataCite |
| 336 | 7 | _ | |a DATA_SET |2 ORCID |
| 336 | 7 | _ | |a ResearchData |2 DINI |
| 520 | _ | _ | |a AlphaFold3 model of LRRK2-pT1343 either bound to GDP/Mg or GTP/Mg. Using AlphaFold3 (Abramson et al., 2024), we modeled and compared the GDP vs the GTP-state of phospho-T1343 LRRK2. Interestingly, the AlphaFold3 model suggests, that the phosphate group of the pT1343 residue is orientated inwards thereby substituting the gamma phosphate of the GTP in the GDP-bound state of LRRK2. This finding is in well agreement with MD simulations published recently (Stormer et al., 2023). |
| 536 | _ | _ | |a 352 - Disease Mechanisms (POF4-352) |0 G:(DE-HGF)POF4-352 |c POF4-352 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to DataCite |
| 650 | _ | 7 | |a structural modeling |2 Other |
| 650 | _ | 7 | |a LRRK2 |2 Other |
| 773 | _ | _ | |a 10.5281/zenodo.11242230 |
| 787 | 0 | _ | |a Gloeckner, Christian Johannes |d Zenodo, 2024 |i RelatedTo |0 DZNE-2024-01346 |r |t Dataset: Supplemental data for 'Intramolecular feedback regulation of the LRRK2 Roc G domain by a LRRK2 kinase dependent mechanism' (Gilsbach et al., eLife 2024, doi:10.7554/eLife.91083), v2 |
| 909 | C | O | |o oai:pub.dzne.de:272966 |p VDB |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 0 |6 P:(DE-2719)2811291 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Neurodegenerative Diseases |1 G:(DE-HGF)POF4-350 |0 G:(DE-HGF)POF4-352 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Disease Mechanisms |x 0 |
| 914 | 1 | _ | |y 2024 |
| 920 | 1 | _ | |0 I:(DE-2719)1210007 |k AG Gloeckner |l Functional Neuroproteomics and Translational Biomarkers in Neurodegenerative Diseases |x 0 |
| 980 | _ | _ | |a dataset |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-2719)1210007 |
| 980 | _ | _ | |a UNRESTRICTED |
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