%0 Journal Article
%A Lau, Yolanda
%A Bansal, Amit
%A Palix, Cassandre
%A Demnitz-King, Harriet
%A Wirth, Miranka
%A Klimecki-Lenz, Olga Maria
%A Chetelat, Gael
%A Poisnel, Géraldine
%A Marchant, Natalie L.
%A Chocat, Anne
%A Collette, Fabienne
%A De La Sayette, Vincent
%A Delarue, Marion
%A Espérou, Hélène
%A Ferrand Devouge, Eglantine
%A Frison, Eric
%A Gonneaud, Julie
%A Jessen, Frank
%A Kaliman, Perla
%A Kuhn, Elizabeth
%A Lefranc, Valérie
%A Lutz, Antoine
%A Ourry, Valentin
%A Quillard, Anne
%A Salmon, Eric
%A Smagghe, Delphine
%A Smith, Rhonda
%A Schlosser, Marco
%A Touron, Edelweiss
%A Wallet, Cédric
%A Whitfield, Tim
%T Sex differences in the association between repetitive negative thinking and neurofilament light
%J npj mental health research
%V 3
%N 1
%@ 2731-4251
%C [London]
%I Nature Publishing Group UK
%M DZNE-2025-00002
%P 53
%D 2024
%X Emerging evidence suggests that repetitive negative thinking (RNT; i.e., worry and ruminative brooding) is associated with biomarkers of Alzheimer's disease. Given that women have a greater risk of many neurodegenerative diseases, this study investigated whether worry and brooding are associated with general neurodegeneration and whether associations differ by sex. Exploratory analyses examined whether allostatic load, a marker of chronic stress, mediates any observed relationships. Baseline data from 134 cognitively healthy older adults in the Age-Well clinical trial were utilised. Worry and brooding were assessed using questionnaires. Plasma neurofilament light chain (NfL), a biomarker of neurodegeneration, was quantified using a Meso Scale Discovery assay. We found a positive interaction between brooding and sex on NfL, with higher brooding associated with greater NfL levels in women. No associations were observed between worry/ruminative brooding and allostatic load. These results offer preliminary support that RNT is associated with worse brain health, specifically in women.
%F PUB:(DE-HGF)16
%9 Journal Article
%2 pmc:PMC11555038
%$ pmid:39528809
%R 10.1038/s44184-024-00093-8
%U https://pub.dzne.de/record/274015