Journal Article

DZNE-2025-00002

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Sex differences in the association between repetitive negative thinking and neurofilament light

Lau, Y. ; Bansal, A. ; Palix, C. ; Demnitz-King, H. ; Wirth, M.DZNE* ; Klimecki-Lenz, O. M.Extern* ; Chetelat, G. ; Poisnel, G. ; Marchant, N. L. ; Chocat, A. ; Collette, F. ; De La Sayette, V. ; Delarue, M. ; Espérou, H. ; Ferrand Devouge, E. ; Frison, E. ; Gonneaud, J. ; Jessen, F.Extern* ; Kaliman, P. ; Kuhn, E.Extern* ; Lefranc, V. ; Lutz, A. ; Ourry, V. ; Quillard, A. ; Salmon, E. ; Smagghe, D. ; Smith, R. ; Schlosser, M. ; Touron, E. ; Wallet, C. ; Whitfield, T.

2024
Nature Publishing Group UK [London]

This record in other databases:    

Please use a persistent id in citations: doi:10.1038/s44184-024-00093-8

Abstract: Emerging evidence suggests that repetitive negative thinking (RNT; i.e., worry and ruminative brooding) is associated with biomarkers of Alzheimer's disease. Given that women have a greater risk of many neurodegenerative diseases, this study investigated whether worry and brooding are associated with general neurodegeneration and whether associations differ by sex. Exploratory analyses examined whether allostatic load, a marker of chronic stress, mediates any observed relationships. Baseline data from 134 cognitively healthy older adults in the Age-Well clinical trial were utilised. Worry and brooding were assessed using questionnaires. Plasma neurofilament light chain (NfL), a biomarker of neurodegeneration, was quantified using a Meso Scale Discovery assay. We found a positive interaction between brooding and sex on NfL, with higher brooding associated with greater NfL levels in women. No associations were observed between worry/ruminative brooding and allostatic load. These results offer preliminary support that RNT is associated with worse brain health, specifically in women.

---

Contributing Institute(s):

1. Brain Resilience (AG Wirth)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

---

Database coverage:
; ; ; ; Article Processing Charges ; DOAJ Seal ; Fees

---

---

Linked articles:

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Journal Article (Erratum/Correction) Lau, Y. ; Bansal, A. ; Palix, C. ; Demnitz-King, H. ; Wirth, M.DZNE* ; Klimecki-Lenz, O. M.Extern* ; Chetelat, G. ; Poisnel, G. ; Marchant, N. L. ; Group, M. R. (Collaboration Author) ; Chocat, A. (Contributor) ; Collette, F. (Contributor) ; De La Sayette, V. (Contributor) ; Delarue, M. (Contributor) ; Espérou, H. (Contributor) ; Ferrand Devouge, E. (Contributor) ; Frison, E. (Contributor) ; Gonneaud, J. (Contributor) ; Jessen, F. (Contributor)Extern* ; Kaliman, P. (Contributor) ; Kuhn, E. (Contributor)Extern* ; Lefranc, V. (Contributor) ; Lutz, A. (Contributor) ; Ourry, V. (Contributor) ; Quillard, A. (Contributor) ; Salmon, E. (Contributor) ; Smagghe, D. (Contributor) ; Smith, R. (Contributor) ; Schlosser, M. (Contributor) ; Touron, E. (Contributor) ; Wallet, C. (Contributor) ; Whitfield, T. (Contributor)
Author Correction: Sex differences in the association between repetitive negative thinking and neurofilament light.
npj mental health research 4(1), 3 (2025) [10.1038/s44184-025-00116-y]2025   Files  Fulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

---