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000274015 1001_ $$aLau, Yolanda$$b0
000274015 245__ $$aSex differences in the association between repetitive negative thinking and neurofilament light
000274015 260__ $$a[London]$$bNature Publishing Group UK$$c2024
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000274015 520__ $$aEmerging evidence suggests that repetitive negative thinking (RNT; i.e., worry and ruminative brooding) is associated with biomarkers of Alzheimer's disease. Given that women have a greater risk of many neurodegenerative diseases, this study investigated whether worry and brooding are associated with general neurodegeneration and whether associations differ by sex. Exploratory analyses examined whether allostatic load, a marker of chronic stress, mediates any observed relationships. Baseline data from 134 cognitively healthy older adults in the Age-Well clinical trial were utilised. Worry and brooding were assessed using questionnaires. Plasma neurofilament light chain (NfL), a biomarker of neurodegeneration, was quantified using a Meso Scale Discovery assay. We found a positive interaction between brooding and sex on NfL, with higher brooding associated with greater NfL levels in women. No associations were observed between worry/ruminative brooding and allostatic load. These results offer preliminary support that RNT is associated with worse brain health, specifically in women.
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000274015 7001_ $$aBansal, Amit$$b1
000274015 7001_ $$aPalix, Cassandre$$b2
000274015 7001_ $$aDemnitz-King, Harriet$$b3
000274015 7001_ $$0P:(DE-2719)2814122$$aWirth, Miranka$$b4
000274015 7001_ $$0P:(DE-2719)9002456$$aKlimecki-Lenz, Olga Maria$$b5$$udzne
000274015 7001_ $$aChetelat, Gael$$b6
000274015 7001_ $$aPoisnel, Géraldine$$b7
000274015 7001_ $$aMarchant, Natalie L.$$b8
000274015 7001_ $$aChocat, Anne$$b9
000274015 7001_ $$aCollette, Fabienne$$b10
000274015 7001_ $$aDe La Sayette, Vincent$$b11
000274015 7001_ $$aDelarue, Marion$$b12
000274015 7001_ $$aEspérou, Hélène$$b13
000274015 7001_ $$aFerrand Devouge, Eglantine$$b14
000274015 7001_ $$aFrison, Eric$$b15
000274015 7001_ $$aGonneaud, Julie$$b16
000274015 7001_ $$0P:(DE-2719)2000032$$aJessen, Frank$$b17$$udzne
000274015 7001_ $$aKaliman, Perla$$b18
000274015 7001_ $$0P:(DE-2719)9002169$$aKuhn, Elizabeth$$b19$$udzne
000274015 7001_ $$aLefranc, Valérie$$b20
000274015 7001_ $$aLutz, Antoine$$b21
000274015 7001_ $$aOurry, Valentin$$b22
000274015 7001_ $$aQuillard, Anne$$b23
000274015 7001_ $$aSalmon, Eric$$b24
000274015 7001_ $$aSmagghe, Delphine$$b25
000274015 7001_ $$aSmith, Rhonda$$b26
000274015 7001_ $$aSchlosser, Marco$$b27
000274015 7001_ $$aTouron, Edelweiss$$b28
000274015 7001_ $$aWallet, Cédric$$b29
000274015 7001_ $$aWhitfield, Tim$$b30
000274015 773__ $$0PERI:(DE-600)3121994-9$$a10.1038/s44184-024-00093-8$$gVol. 3, no. 1, p. 53$$n1$$p53$$tnpj mental health research$$v3$$x2731-4251$$y2024
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