TY  - JOUR
AU  - Lau, Yolanda
AU  - Bansal, Amit
AU  - Palix, Cassandre
AU  - Demnitz-King, Harriet
AU  - Wirth, Miranka
AU  - Klimecki-Lenz, Olga Maria
AU  - Chetelat, Gael
AU  - Poisnel, Géraldine
AU  - Marchant, Natalie L.
AU  - Chocat, Anne
AU  - Collette, Fabienne
AU  - De La Sayette, Vincent
AU  - Delarue, Marion
AU  - Espérou, Hélène
AU  - Ferrand Devouge, Eglantine
AU  - Frison, Eric
AU  - Gonneaud, Julie
AU  - Jessen, Frank
AU  - Kaliman, Perla
AU  - Kuhn, Elizabeth
AU  - Lefranc, Valérie
AU  - Lutz, Antoine
AU  - Ourry, Valentin
AU  - Quillard, Anne
AU  - Salmon, Eric
AU  - Smagghe, Delphine
AU  - Smith, Rhonda
AU  - Schlosser, Marco
AU  - Touron, Edelweiss
AU  - Wallet, Cédric
AU  - Whitfield, Tim
TI  - Sex differences in the association between repetitive negative thinking and neurofilament light
JO  - npj mental health research
VL  - 3
IS  - 1
SN  - 2731-4251
CY  - [London]
PB  - Nature Publishing Group UK
M1  - DZNE-2025-00002
SP  - 53
PY  - 2024
AB  - Emerging evidence suggests that repetitive negative thinking (RNT; i.e., worry and ruminative brooding) is associated with biomarkers of Alzheimer's disease. Given that women have a greater risk of many neurodegenerative diseases, this study investigated whether worry and brooding are associated with general neurodegeneration and whether associations differ by sex. Exploratory analyses examined whether allostatic load, a marker of chronic stress, mediates any observed relationships. Baseline data from 134 cognitively healthy older adults in the Age-Well clinical trial were utilised. Worry and brooding were assessed using questionnaires. Plasma neurofilament light chain (NfL), a biomarker of neurodegeneration, was quantified using a Meso Scale Discovery assay. We found a positive interaction between brooding and sex on NfL, with higher brooding associated with greater NfL levels in women. No associations were observed between worry/ruminative brooding and allostatic load. These results offer preliminary support that RNT is associated with worse brain health, specifically in women.
LB  - PUB:(DE-HGF)16
C2  - pmc:PMC11555038
C6  - pmid:39528809
DO  - DOI:10.1038/s44184-024-00093-8
UR  - https://pub.dzne.de/record/274015
ER  -