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@ARTICLE{Lau:274015,
      author       = {Lau, Yolanda and Bansal, Amit and Palix, Cassandre and
                      Demnitz-King, Harriet and Wirth, Miranka and Klimecki-Lenz,
                      Olga Maria and Chetelat, Gael and Poisnel, Géraldine and
                      Marchant, Natalie L. and Chocat, Anne and Collette, Fabienne
                      and De La Sayette, Vincent and Delarue, Marion and Espérou,
                      Hélène and Ferrand Devouge, Eglantine and Frison, Eric and
                      Gonneaud, Julie and Jessen, Frank and Kaliman, Perla and
                      Kuhn, Elizabeth and Lefranc, Valérie and Lutz, Antoine and
                      Ourry, Valentin and Quillard, Anne and Salmon, Eric and
                      Smagghe, Delphine and Smith, Rhonda and Schlosser, Marco and
                      Touron, Edelweiss and Wallet, Cédric and Whitfield, Tim},
      title        = {{S}ex differences in the association between repetitive
                      negative thinking and neurofilament light},
      journal      = {npj mental health research},
      volume       = {3},
      number       = {1},
      issn         = {2731-4251},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DZNE-2025-00002},
      pages        = {53},
      year         = {2024},
      abstract     = {Emerging evidence suggests that repetitive negative
                      thinking (RNT; i.e., worry and ruminative brooding) is
                      associated with biomarkers of Alzheimer's disease. Given
                      that women have a greater risk of many neurodegenerative
                      diseases, this study investigated whether worry and brooding
                      are associated with general neurodegeneration and whether
                      associations differ by sex. Exploratory analyses examined
                      whether allostatic load, a marker of chronic stress,
                      mediates any observed relationships. Baseline data from 134
                      cognitively healthy older adults in the Age-Well clinical
                      trial were utilised. Worry and brooding were assessed using
                      questionnaires. Plasma neurofilament light chain (NfL), a
                      biomarker of neurodegeneration, was quantified using a Meso
                      Scale Discovery assay. We found a positive interaction
                      between brooding and sex on NfL, with higher brooding
                      associated with greater NfL levels in women. No associations
                      were observed between worry/ruminative brooding and
                      allostatic load. These results offer preliminary support
                      that RNT is associated with worse brain health, specifically
                      in women.},
      cin          = {AG Wirth},
      cid          = {I:(DE-2719)1710011},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC11555038},
      pubmed       = {pmid:39528809},
      doi          = {10.1038/s44184-024-00093-8},
      url          = {https://pub.dzne.de/record/274015},
}