guest ::
| Home > Publications Database > Sex differences in the association between repetitive negative thinking and neurofilament light > print |
| Home > Publications Database > Sex differences in the association between repetitive negative thinking and neurofilament light > print |
| 001 | 274015 | ||
| 005 | 20250127091417.0 | ||
| 024 | 7 | _ | |a pmc:PMC11555038 |2 pmc |
| 024 | 7 | _ | |a 10.1038/s44184-024-00093-8 |2 doi |
| 024 | 7 | _ | |a altmetric:170322879 |2 altmetric |
| 024 | 7 | _ | |a pmid:39528809 |2 pmid |
| 037 | _ | _ | |a DZNE-2025-00002 |
| 041 | _ | _ | |a English |
| 100 | 1 | _ | |a Lau, Yolanda |b 0 |
| 245 | _ | _ | |a Sex differences in the association between repetitive negative thinking and neurofilament light |
| 260 | _ | _ | |a [London] |c 2024 |b Nature Publishing Group UK |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1736237653_12692 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Emerging evidence suggests that repetitive negative thinking (RNT; i.e., worry and ruminative brooding) is associated with biomarkers of Alzheimer's disease. Given that women have a greater risk of many neurodegenerative diseases, this study investigated whether worry and brooding are associated with general neurodegeneration and whether associations differ by sex. Exploratory analyses examined whether allostatic load, a marker of chronic stress, mediates any observed relationships. Baseline data from 134 cognitively healthy older adults in the Age-Well clinical trial were utilised. Worry and brooding were assessed using questionnaires. Plasma neurofilament light chain (NfL), a biomarker of neurodegeneration, was quantified using a Meso Scale Discovery assay. We found a positive interaction between brooding and sex on NfL, with higher brooding associated with greater NfL levels in women. No associations were observed between worry/ruminative brooding and allostatic load. These results offer preliminary support that RNT is associated with worse brain health, specifically in women. |
| 536 | _ | _ | |a 353 - Clinical and Health Care Research (POF4-353) |0 G:(DE-HGF)POF4-353 |c POF4-353 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to DataCite |
| 700 | 1 | _ | |a Bansal, Amit |b 1 |
| 700 | 1 | _ | |a Palix, Cassandre |b 2 |
| 700 | 1 | _ | |a Demnitz-King, Harriet |b 3 |
| 700 | 1 | _ | |a Wirth, Miranka |0 P:(DE-2719)2814122 |b 4 |
| 700 | 1 | _ | |a Klimecki-Lenz, Olga Maria |0 P:(DE-2719)9002456 |b 5 |u dzne |
| 700 | 1 | _ | |a Chetelat, Gael |b 6 |
| 700 | 1 | _ | |a Poisnel, Géraldine |b 7 |
| 700 | 1 | _ | |a Marchant, Natalie L. |b 8 |
| 700 | 1 | _ | |a Chocat, Anne |b 9 |
| 700 | 1 | _ | |a Collette, Fabienne |b 10 |
| 700 | 1 | _ | |a De La Sayette, Vincent |b 11 |
| 700 | 1 | _ | |a Delarue, Marion |b 12 |
| 700 | 1 | _ | |a Espérou, Hélène |b 13 |
| 700 | 1 | _ | |a Ferrand Devouge, Eglantine |b 14 |
| 700 | 1 | _ | |a Frison, Eric |b 15 |
| 700 | 1 | _ | |a Gonneaud, Julie |b 16 |
| 700 | 1 | _ | |a Jessen, Frank |0 P:(DE-2719)2000032 |b 17 |u dzne |
| 700 | 1 | _ | |a Kaliman, Perla |b 18 |
| 700 | 1 | _ | |a Kuhn, Elizabeth |0 P:(DE-2719)9002169 |b 19 |u dzne |
| 700 | 1 | _ | |a Lefranc, Valérie |b 20 |
| 700 | 1 | _ | |a Lutz, Antoine |b 21 |
| 700 | 1 | _ | |a Ourry, Valentin |b 22 |
| 700 | 1 | _ | |a Quillard, Anne |b 23 |
| 700 | 1 | _ | |a Salmon, Eric |b 24 |
| 700 | 1 | _ | |a Smagghe, Delphine |b 25 |
| 700 | 1 | _ | |a Smith, Rhonda |b 26 |
| 700 | 1 | _ | |a Schlosser, Marco |b 27 |
| 700 | 1 | _ | |a Touron, Edelweiss |b 28 |
| 700 | 1 | _ | |a Wallet, Cédric |b 29 |
| 700 | 1 | _ | |a Whitfield, Tim |b 30 |
| 773 | _ | _ | |a 10.1038/s44184-024-00093-8 |g Vol. 3, no. 1, p. 53 |0 PERI:(DE-600)3121994-9 |n 1 |p 53 |t npj mental health research |v 3 |y 2024 |x 2731-4251 |
| 856 | 4 | _ | |y OpenAccess |u https://pub.dzne.de/record/274015/files/DZNE-2025-00002.pdf |
| 856 | 4 | _ | |y OpenAccess |x pdfa |u https://pub.dzne.de/record/274015/files/DZNE-2025-00002.pdf?subformat=pdfa |
| 909 | C | O | |o oai:pub.dzne.de:274015 |p openaire |p open_access |p VDB |p driver |p dnbdelivery |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 4 |6 P:(DE-2719)2814122 |
| 910 | 1 | _ | |a External Institute |0 I:(DE-HGF)0 |k Extern |b 5 |6 P:(DE-2719)9002456 |
| 910 | 1 | _ | |a External Institute |0 I:(DE-HGF)0 |k Extern |b 17 |6 P:(DE-2719)2000032 |
| 910 | 1 | _ | |a External Institute |0 I:(DE-HGF)0 |k Extern |b 19 |6 P:(DE-2719)9002169 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Neurodegenerative Diseases |1 G:(DE-HGF)POF4-350 |0 G:(DE-HGF)POF4-353 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Clinical and Health Care Research |x 0 |
| 915 | _ | _ | |a Creative Commons Attribution CC BY 4.0 |0 LIC:(DE-HGF)CCBY4 |2 HGFVOC |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0501 |2 StatID |b DOAJ Seal |d 2023-03-21T16:19:07Z |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0500 |2 StatID |b DOAJ |d 2023-03-21T16:19:07Z |
| 915 | _ | _ | |a OpenAccess |0 StatID:(DE-HGF)0510 |2 StatID |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b DOAJ : Peer review, Anonymous peer review |d 2023-03-21T16:19:07Z |
| 915 | _ | _ | |a Article Processing Charges |0 StatID:(DE-HGF)0561 |2 StatID |d 2023-09-02 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2023-09-02 |
| 915 | _ | _ | |a Fees |0 StatID:(DE-HGF)0700 |2 StatID |d 2023-09-02 |
| 920 | _ | _ | |l yes |
| 920 | 1 | _ | |0 I:(DE-2719)1710011 |k AG Wirth |l Brain Resilience |x 0 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a UNRESTRICTED |
| 980 | _ | _ | |a I:(DE-2719)1710011 |
| 980 | 1 | _ | |a FullTexts |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|