000274054 001__ 274054
000274054 005__ 20250119000304.0
000274054 0247_ $$2doi$$a10.1038/s41598-024-81071-0
000274054 0247_ $$2pmid$$apmid:39695314
000274054 0247_ $$2pmc$$apmc:PMC11655979
000274054 0247_ $$2altmetric$$aaltmetric:172236615
000274054 037__ $$aDZNE-2025-00035
000274054 041__ $$aEnglish
000274054 082__ $$a600
000274054 1001_ $$aTsamitros, N.$$b0
000274054 245__ $$aCraving induction through virtual reality cue-exposure for patients with alcohol dependence in rehabilitation treatment.
000274054 260__ $$a[London]$$bMacmillan Publishers Limited, part of Springer Nature$$c2024
000274054 3367_ $$2DRIVER$$aarticle
000274054 3367_ $$2DataCite$$aOutput Types/Journal article
000274054 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1736341868_8154
000274054 3367_ $$2BibTeX$$aARTICLE
000274054 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000274054 3367_ $$00$$2EndNote$$aJournal Article
000274054 520__ $$aNew therapeutic approaches for alcohol dependence (AD) include virtual reality (VR)-based treatments offering scalable options for cue exposure (CE), a well-established strategy in cognitive behavioral therapy. This study aimed to evaluate the feasibility and tolerability of a new VR-CE paradigm. On an explorative basis, factors influencing the induction of craving were examined. This single-arm monocentric clinical study included n = 21 patients with AD in inpatient rehabilitation treatment, that completed one VR-CE session including confrontation with alcohol-associated stimuli. Measurements of subjective craving before, during and after exposure, affective states, VR side effects as cybersickness and the sense of presence in VR were conducted. Craving levels during and directly after VR-CE were significantly higher than before the intervention. Craving levels 20 min after VR-CE did not significantly differ compared to those before VR-CE. Patients described a pronounced sense of presence and only mild symptoms of cybersickness. Craving was significantly correlated with cybersickness. While positive affect decreased throughout the VR exposure, negative affect did not differ significantly in pre-post-comparisons. This study shows that craving induction through our VR-CE paradigm is feasible and well-tolerated by patients with AD in long-term rehabilitation. These results contribute to the development and future research of therapeutic VR-CE approaches.
000274054 536__ $$0G:(DE-HGF)POF4-353$$a353 - Clinical and Health Care Research (POF4-353)$$cPOF4-353$$fPOF IV$$x0
000274054 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
000274054 650_7 $$2Other$$aAlcohol dependence
000274054 650_7 $$2Other$$aCraving
000274054 650_7 $$2Other$$aCue exposure
000274054 650_7 $$2Other$$aCybersickness
000274054 650_7 $$2Other$$aSense of presence
000274054 650_7 $$2Other$$aVirtual reality
000274054 650_2 $$2MeSH$$aHumans
000274054 650_2 $$2MeSH$$aAlcoholism: rehabilitation
000274054 650_2 $$2MeSH$$aAlcoholism: psychology
000274054 650_2 $$2MeSH$$aMale
000274054 650_2 $$2MeSH$$aCraving
000274054 650_2 $$2MeSH$$aFemale
000274054 650_2 $$2MeSH$$aMiddle Aged
000274054 650_2 $$2MeSH$$aAdult
000274054 650_2 $$2MeSH$$aCues
000274054 650_2 $$2MeSH$$aVirtual Reality
000274054 650_2 $$2MeSH$$aVirtual Reality Exposure Therapy: methods
000274054 650_2 $$2MeSH$$aCognitive Behavioral Therapy: methods
000274054 7001_ $$aGutwinski, S.$$b1
000274054 7001_ $$aBeck, A.$$b2
000274054 7001_ $$aLange Mussons, S.$$b3
000274054 7001_ $$aSebold, M.$$b4
000274054 7001_ $$aSchöneck, R.$$b5
000274054 7001_ $$0P:(DE-2719)2810583$$aWolbers, T.$$b6$$udzne
000274054 7001_ $$aBermpohl, F.$$b7
000274054 7001_ $$aHeinz, A.$$b8
000274054 7001_ $$aLütt, A.$$b9
000274054 773__ $$0PERI:(DE-600)2615211-3$$a10.1038/s41598-024-81071-0$$gVol. 14, no. 1, p. 30550$$n1$$p30550$$tScientific reports$$v14$$x2045-2322$$y2024
000274054 8564_ $$uhttps://pub.dzne.de/record/274054/files/DZNE-2025-00035.pdf$$yOpenAccess
000274054 8564_ $$uhttps://pub.dzne.de/record/274054/files/DZNE-2025-00035.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000274054 909CO $$ooai:pub.dzne.de:274054$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
000274054 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810583$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b6$$kDZNE
000274054 9131_ $$0G:(DE-HGF)POF4-353$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vClinical and Health Care Research$$x0
000274054 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000274054 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-08-24
000274054 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2023-08-24
000274054 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2023-08-24
000274054 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2023-08-24
000274054 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2023-08-24
000274054 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record$$d2023-08-24
000274054 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bSCI REP-UK : 2022$$d2023-08-24
000274054 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2023-04-12T15:11:06Z
000274054 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2023-04-12T15:11:06Z
000274054 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2023-08-24
000274054 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2023-08-24
000274054 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-08-24
000274054 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2023-08-24
000274054 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000274054 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2023-08-24
000274054 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2023-08-24
000274054 915__ $$0StatID:(DE-HGF)1150$$2StatID$$aDBCoverage$$bCurrent Contents - Physical, Chemical and Earth Sciences$$d2023-08-24
000274054 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-08-24
000274054 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central$$d2023-08-24
000274054 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-08-24
000274054 9201_ $$0I:(DE-2719)1310002$$kAG Wolbers$$lAging, Cognition and Technology$$x0
000274054 980__ $$ajournal
000274054 980__ $$aVDB
000274054 980__ $$aUNRESTRICTED
000274054 980__ $$aI:(DE-2719)1310002
000274054 9801_ $$aFullTexts