TY  - JOUR
AU  - Montejo, Laura
AU  - Sole, Brisa
AU  - Fico, Giovanna
AU  - Kalman, Janos L.
AU  - Budde, Monika
AU  - Heilbronner, Urs
AU  - Oliva, Vincenzo
AU  - De Prisco, Michele
AU  - Martin-Parra, Sara
AU  - Ruiz, Andrea
AU  - Martinez-Aran, Anabel
AU  - Adorjan, Kristina
AU  - Falkai, Peter
AU  - Heilbronner, Maria
AU  - Kohshour, Mojtaba Oraki
AU  - Reich-Erkelenz, Daniela
AU  - Schaupp, Sabrina K.
AU  - Schulte, Eva C.
AU  - Senner, Fanny
AU  - Vogl, Thomas
AU  - Anghelescu, Ion-George
AU  - Arolt, Volker
AU  - Baune, Bernhard T.
AU  - Dannlowski, Udo
AU  - Dietrich, Detlef E.
AU  - Fallgatter, Andreas J.
AU  - Figge, Christian
AU  - Juckel, Georg
AU  - Konrad, Carsten
AU  - Reimer, Jens
AU  - Reininghaus, Eva Z.
AU  - Schmauß, Max
AU  - Wiltfang, Jens
AU  - Zimmermann, Jörg
AU  - Vieta, Eduard
AU  - Papiol, Sergi
AU  - Schulze, Thomas G.
AU  - Torrent, Carla
TI  - Contrasting genetic burden for bipolar disorder: Early onset versus late onset in an older adult bipolar disorder sample
JO  - European neuropsychopharmacology
VL  - 92
SN  - 0924-977X
CY  - Amsterdam
PB  - Elsevier
M1  - DZNE-2025-00052
SP  - 29 - 37
PY  - 2025
AB  - Older Adults with Bipolar Disorder (OABD) represent a heterogeneous group, including those with early and late onset of the disorder. Recent evidence shows both groups have distinct clinical, cognitive, and medical features, tied to different neurobiological profiles. This study explored the link between polygenic risk scores (PRS) for bipolar disorder (PRS-BD), schizophrenia (PRS-SCZ), and major depressive disorder (PRS-MDD) with age of onset in OABD. PRS-SCZ, PRS-BD, and PRS-MDD among early vs late onset were calculated. PRS was used to infer posterior SNP effect sizes using a fully Bayesian approach. Demographic, clinical, and cognitive variables were also analyzed. Logistic regression analysis was used to estimate the amount of variation of each group explained by standardized PRS-SCZ, PRS-MDD, and PRS-BD. A total of 207 OABD subjects were included (144 EOBD; 63 LOBD). EOBD showed higher PRS-BD compared to LOBD (p = 0.005), while no association was found between age of onset and PRS-SCZ or PRS-MDD. Compared to LOBD, EOBD individuals also showed a higher likelihood for suicide attempts (p = 0.01), higher presence of psychotic symptoms (p = 0.003), higher prevalence of BD-I (p = 0.002), higher rates of familiarity for any psychiatric disorder (p = 0.004), and lower processing speed measured with Trail-Making Test part A (p = 0.03). OABD subjects with an early onset showed a greater genetic burden for BD compared to subjects with a late onset. These findings contribute to the notion that EOBD and LOBD may represent different forms of OABD, particularly regarding the genetic predisposition to BD.
LB  - PUB:(DE-HGF)16
C6  - pmid:39718074
DO  - DOI:10.1016/j.euroneuro.2024.12.001
UR  - https://pub.dzne.de/record/274096
ER  -