Journal Article

DZNE-2025-00052

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Contrasting genetic burden for bipolar disorder: Early onset versus late onset in an older adult bipolar disorder sample

Montejo, L. ; Sole, B. ; Fico, G. ; Kalman, J. L. ; Budde, M. ; Heilbronner, U. ; Oliva, V. ; De Prisco, M. ; Martin-Parra, S. ; Ruiz, A. ; Martinez-Aran, A. ; Adorjan, K. ; Falkai, P. ; Heilbronner, M. ; Kohshour, M. O. ; Reich-Erkelenz, D. ; Schaupp, S. K. ; Schulte, E. C. ; Senner, F. ; Vogl, T. ; Anghelescu, I.-G. ; Arolt, V. ; Baune, B. T. ; Dannlowski, U. ; Dietrich, D. E. ; Fallgatter, A. J. ; Figge, C. ; Juckel, G. ; Konrad, C. ; Reimer, J. ; Reininghaus, E. Z. ; Schmauß, M. ; Wiltfang, J.DZNE* ; Zimmermann, J. ; Vieta, E. ; Papiol, S. ; Schulze, T. G. ; Torrent, C.

2025
Elsevier Amsterdam

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Please use a persistent id in citations: doi:10.1016/j.euroneuro.2024.12.001

Abstract: Older Adults with Bipolar Disorder (OABD) represent a heterogeneous group, including those with early and late onset of the disorder. Recent evidence shows both groups have distinct clinical, cognitive, and medical features, tied to different neurobiological profiles. This study explored the link between polygenic risk scores (PRS) for bipolar disorder (PRS-BD), schizophrenia (PRS-SCZ), and major depressive disorder (PRS-MDD) with age of onset in OABD. PRS-SCZ, PRS-BD, and PRS-MDD among early vs late onset were calculated. PRS was used to infer posterior SNP effect sizes using a fully Bayesian approach. Demographic, clinical, and cognitive variables were also analyzed. Logistic regression analysis was used to estimate the amount of variation of each group explained by standardized PRS-SCZ, PRS-MDD, and PRS-BD. A total of 207 OABD subjects were included (144 EOBD; 63 LOBD). EOBD showed higher PRS-BD compared to LOBD (p = 0.005), while no association was found between age of onset and PRS-SCZ or PRS-MDD. Compared to LOBD, EOBD individuals also showed a higher likelihood for suicide attempts (p = 0.01), higher presence of psychotic symptoms (p = 0.003), higher prevalence of BD-I (p = 0.002), higher rates of familiarity for any psychiatric disorder (p = 0.004), and lower processing speed measured with Trail-Making Test part A (p = 0.03). OABD subjects with an early onset showed a greater genetic burden for BD compared to subjects with a late onset. These findings contribute to the notion that EOBD and LOBD may represent different forms of OABD, particularly regarding the genetic predisposition to BD.

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Contributing Institute(s):

1. Molecular biomarkers for predictive diagnostics of neurodegenerative diseases (AG Wiltfang)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2025

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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