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@ARTICLE{Montejo:274096,
      author       = {Montejo, Laura and Sole, Brisa and Fico, Giovanna and
                      Kalman, Janos L. and Budde, Monika and Heilbronner, Urs and
                      Oliva, Vincenzo and De Prisco, Michele and Martin-Parra,
                      Sara and Ruiz, Andrea and Martinez-Aran, Anabel and Adorjan,
                      Kristina and Falkai, Peter and Heilbronner, Maria and
                      Kohshour, Mojtaba Oraki and Reich-Erkelenz, Daniela and
                      Schaupp, Sabrina K. and Schulte, Eva C. and Senner, Fanny
                      and Vogl, Thomas and Anghelescu, Ion-George and Arolt,
                      Volker and Baune, Bernhard T. and Dannlowski, Udo and
                      Dietrich, Detlef E. and Fallgatter, Andreas J. and Figge,
                      Christian and Juckel, Georg and Konrad, Carsten and Reimer,
                      Jens and Reininghaus, Eva Z. and Schmauß, Max and Wiltfang,
                      Jens and Zimmermann, Jörg and Vieta, Eduard and Papiol,
                      Sergi and Schulze, Thomas G. and Torrent, Carla},
      title        = {{C}ontrasting genetic burden for bipolar disorder: {E}arly
                      onset versus late onset in an older adult bipolar disorder
                      sample},
      journal      = {European neuropsychopharmacology},
      volume       = {92},
      issn         = {0924-977X},
      address      = {Amsterdam},
      publisher    = {Elsevier},
      reportid     = {DZNE-2025-00052},
      pages        = {29 - 37},
      year         = {2025},
      abstract     = {Older Adults with Bipolar Disorder (OABD) represent a
                      heterogeneous group, including those with early and late
                      onset of the disorder. Recent evidence shows both groups
                      have distinct clinical, cognitive, and medical features,
                      tied to different neurobiological profiles. This study
                      explored the link between polygenic risk scores (PRS) for
                      bipolar disorder (PRS-BD), schizophrenia (PRS-SCZ), and
                      major depressive disorder (PRS-MDD) with age of onset in
                      OABD. PRS-SCZ, PRS-BD, and PRS-MDD among early vs late onset
                      were calculated. PRS was used to infer posterior SNP effect
                      sizes using a fully Bayesian approach. Demographic,
                      clinical, and cognitive variables were also analyzed.
                      Logistic regression analysis was used to estimate the amount
                      of variation of each group explained by standardized
                      PRS-SCZ, PRS-MDD, and PRS-BD. A total of 207 OABD subjects
                      were included (144 EOBD; 63 LOBD). EOBD showed higher PRS-BD
                      compared to LOBD (p = 0.005), while no association was found
                      between age of onset and PRS-SCZ or PRS-MDD. Compared to
                      LOBD, EOBD individuals also showed a higher likelihood for
                      suicide attempts (p = 0.01), higher presence of psychotic
                      symptoms (p = 0.003), higher prevalence of BD-I (p = 0.002),
                      higher rates of familiarity for any psychiatric disorder (p
                      = 0.004), and lower processing speed measured with
                      Trail-Making Test part A (p = 0.03). OABD subjects with an
                      early onset showed a greater genetic burden for BD compared
                      to subjects with a late onset. These findings contribute to
                      the notion that EOBD and LOBD may represent different forms
                      of OABD, particularly regarding the genetic predisposition
                      to BD.},
      cin          = {AG Wiltfang},
      ddc          = {610},
      cid          = {I:(DE-2719)1410006},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39718074},
      doi          = {10.1016/j.euroneuro.2024.12.001},
      url          = {https://pub.dzne.de/record/274096},
}