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@ARTICLE{Colonna:275837,
      author       = {Colonna, Marco and Konopka, Genevieve and Liddelow, Shane A
                      and Nowakowski, Tomasz and Awatramani, Rajeshwar and Bateup,
                      Helen S and Cadwell, Cathryn R and Caglayan, Emre and Chen,
                      Jerry L and Gillis, Jesse and Kampmann, Martin and Krienen,
                      Fenna and Marsh, Samuel E and Monje, Michelle and O'Dea,
                      Michael R and Patani, Rickie and Pollen, Alex A and
                      Quintana, Francisco J and Scavuzzo, Marissa and Schmitz,
                      Matthew and Sloan, Steven A and Tesar, Paul J and Tollkuhn,
                      Jessica and Tosches, Maria Antonietta and Urbanek, Madeleine
                      E and Werner, Jonathan M and Bayraktar, Omer A and Gokce,
                      Ozgun and Habib, Naomi},
      title        = {{I}mplementation and validation of single-cell genomics
                      experiments in neuroscience.},
      journal      = {Nature neuroscience},
      volume       = {27},
      number       = {12},
      issn         = {1097-6256},
      address      = {New York, NY},
      publisher    = {Nature America},
      reportid     = {DZNE-2025-00072},
      pages        = {2310 - 2325},
      year         = {2024},
      abstract     = {Single-cell or single-nucleus transcriptomics is a powerful
                      tool for identifying cell types and cell states. However,
                      hypotheses derived from these assays, including gene
                      expression information, require validation, and their
                      functional relevance needs to be established. The choice of
                      validation depends on numerous factors. Here, we present
                      types of orthogonal and functional validation experiment to
                      strengthen preliminary findings obtained using single-cell
                      and single-nucleus transcriptomics as well as the challenges
                      and limitations of these approaches.},
      subtyp        = {Review Article},
      keywords     = {Single-Cell Analysis: methods / Neurosciences: methods /
                      Animals / Genomics: methods / Humans / Transcriptome / Gene
                      Expression Profiling: methods},
      cin          = {AG Gokce},
      ddc          = {610},
      cid          = {I:(DE-2719)1013041},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39627589},
      doi          = {10.1038/s41593-024-01814-0},
      url          = {https://pub.dzne.de/record/275837},
}