TY  - JOUR
AU  - Adameyko, Igor
AU  - Bakken, Trygve
AU  - Bhaduri, Aparna
AU  - Chhatbar, Chintan
AU  - Filbin, Mariella G
AU  - Gate, David
AU  - Hochgerner, Hannah
AU  - Kim, Chang Nam
AU  - Krull, Jordan
AU  - La Manno, Gioele
AU  - Li, Qingyun
AU  - Linnarsson, Sten
AU  - Ma, Qin
AU  - Mayer, Christian
AU  - Menon, Vilas
AU  - Nano, Patricia
AU  - Prinz, Marco
AU  - Quake, Steve
AU  - Walsh, Christopher A
AU  - Yang, Jin
AU  - Bayraktar, Omer Ali
AU  - Gokce, Ozgun
AU  - Habib, Naomi
AU  - Konopka, Genevieve
AU  - Liddelow, Shane A
AU  - Nowakowski, Tomasz J
TI  - Applying single-cell and single-nucleus genomics to studies of cellular heterogeneity and cell fate transitions in the nervous system.
JO  - Nature neuroscience
VL  - 27
IS  - 12
SN  - 1097-6256
CY  - New York, NY
PB  - Nature America
M1  - DZNE-2025-00073
SP  - 2278 - 2291
PY  - 2024
AB  - Single-cell and single-nucleus genomic approaches can provide unbiased and multimodal insights. Here, we discuss what constitutes a molecular cell atlas and how to leverage single-cell omics data to generate hypotheses and gain insights into cell transitions in development and disease of the nervous system. We share points of reflection on what to consider during study design and implementation as well as limitations and pitfalls.
KW  - Animals
KW  - Humans
KW  - Cell Differentiation: genetics
KW  - Cell Nucleus: metabolism
KW  - Cell Nucleus: genetics
KW  - Genomics: methods
KW  - Nervous System: cytology
KW  - Nervous System: metabolism
KW  - Single-Cell Analysis: methods
LB  - PUB:(DE-HGF)16
C6  - pmid:39627588
DO  - DOI:10.1038/s41593-024-01827-9
UR  - https://pub.dzne.de/record/275838
ER  -