Journal Article (Review Article)

DZNE-2025-00073

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Applying single-cell and single-nucleus genomics to studies of cellular heterogeneity and cell fate transitions in the nervous system.

Adameyko, I. ; Bakken, T. ; Bhaduri, A. ; Chhatbar, C. ; Filbin, M. G. ; Gate, D. ; Hochgerner, H. ; Kim, C. N. ; Krull, J. ; La Manno, G. ; Li, Q. ; Linnarsson, S. ; Ma, Q. ; Mayer, C. ; Menon, V. ; Nano, P. ; Prinz, M. ; Quake, S. ; Walsh, C. A. ; Yang, J. ; Bayraktar, O. A. ; Gokce, O.DZNE* ; Habib, N. ; Konopka, G. ; Liddelow, S. A. ; Nowakowski, T. J.

2024
Nature America New York, NY

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Please use a persistent id in citations: doi:10.1038/s41593-024-01827-9

Abstract: Single-cell and single-nucleus genomic approaches can provide unbiased and multimodal insights. Here, we discuss what constitutes a molecular cell atlas and how to leverage single-cell omics data to generate hypotheses and gain insights into cell transitions in development and disease of the nervous system. We share points of reflection on what to consider during study design and implementation as well as limitations and pitfalls.

Keyword(s): Animals (MeSH) ; Humans (MeSH) ; Cell Differentiation: genetics (MeSH) ; Cell Nucleus: metabolism (MeSH) ; Cell Nucleus: genetics (MeSH) ; Genomics: methods (MeSH) ; Nervous System: cytology (MeSH) ; Nervous System: metabolism (MeSH) ; Single-Cell Analysis: methods (MeSH)

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Contributing Institute(s):

1. Spatial Dynamics of Neurodegeneration (AG Gokce)

Research Program(s):

1. 351 - Brain Function (POF4-351) (POF4-351)

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Nature ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 25 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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