Home > Publications Database > Applying single-cell and single-nucleus genomics to studies of cellular heterogeneity and cell fate transitions in the nervous system. > print

001     275838
005     20260212170140.0
024 7 _ |2 doi
|a 10.1038/s41593-024-01827-9
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|a pmid:39627588
024 7 _ |2 ISSN
|a 1097-6256
024 7 _ |2 ISSN
|a 1546-1726
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037 _ _ |a DZNE-2025-00073
041 _ _ |a English
082 _ _ |a 610
100 1 _ |0 0000-0001-5471-0356
|a Adameyko, Igor
|b 0
245 _ _ |a Applying single-cell and single-nucleus genomics to studies of cellular heterogeneity and cell fate transitions in the nervous system.
260 _ _ |a New York, NY
|b Nature America
|c 2024
336 7 _ |2 DRIVER
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336 7 _ |2 BibTeX
|a ARTICLE
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520 _ _ |a Single-cell and single-nucleus genomic approaches can provide unbiased and multimodal insights. Here, we discuss what constitutes a molecular cell atlas and how to leverage single-cell omics data to generate hypotheses and gain insights into cell transitions in development and disease of the nervous system. We share points of reflection on what to consider during study design and implementation as well as limitations and pitfalls.
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650 _ 2 |2 MeSH
|a Animals
650 _ 2 |2 MeSH
|a Humans
650 _ 2 |2 MeSH
|a Cell Differentiation: genetics
650 _ 2 |2 MeSH
|a Cell Nucleus: metabolism
650 _ 2 |2 MeSH
|a Cell Nucleus: genetics
650 _ 2 |2 MeSH
|a Genomics: methods
650 _ 2 |2 MeSH
|a Nervous System: cytology
650 _ 2 |2 MeSH
|a Nervous System: metabolism
650 _ 2 |2 MeSH
|a Single-Cell Analysis: methods
700 1 _ |0 0000-0003-3373-7386
|a Bakken, Trygve
|b 1
700 1 _ |0 0000-0003-4625-6899
|a Bhaduri, Aparna
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700 1 _ |0 0000-0002-5824-5209
|a Chhatbar, Chintan
|b 3
700 1 _ |a Filbin, Mariella G
|b 4
700 1 _ |0 0000-0003-0481-9657
|a Gate, David
|b 5
700 1 _ |0 0000-0002-7739-666X
|a Hochgerner, Hannah
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700 1 _ |0 0000-0001-7921-4447
|a Kim, Chang Nam
|b 7
700 1 _ |0 0000-0001-6507-8085
|a Krull, Jordan
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700 1 _ |0 0000-0003-1428-8757
|a La Manno, Gioele
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700 1 _ |0 0000-0002-3457-5967
|a Li, Qingyun
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700 1 _ |0 0000-0002-3491-3444
|a Linnarsson, Sten
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700 1 _ |0 0000-0002-3264-8392
|a Ma, Qin
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700 1 _ |0 0000-0003-3152-5574
|a Mayer, Christian
|b 13
700 1 _ |0 0000-0002-4096-8601
|a Menon, Vilas
|b 14
700 1 _ |0 0000-0002-5507-2656
|a Nano, Patricia
|b 15
700 1 _ |0 0000-0002-0349-1955
|a Prinz, Marco
|b 16
700 1 _ |a Quake, Steve
|b 17
700 1 _ |0 0000-0002-0156-2238
|a Walsh, Christopher A
|b 18
700 1 _ |a Yang, Jin
|b 19
700 1 _ |0 0000-0001-6055-277X
|a Bayraktar, Omer Ali
|b 20
700 1 _ |0 P:(DE-2719)9002754
|a Gokce, Ozgun
|b 21
700 1 _ |0 0000-0002-6049-2487
|a Habib, Naomi
|b 22
700 1 _ |0 0000-0002-3363-7302
|a Konopka, Genevieve
|b 23
700 1 _ |0 0000-0002-0840-1437
|a Liddelow, Shane A
|b 24
700 1 _ |0 0000-0003-2345-4964
|a Nowakowski, Tomasz J
|b 25
773 _ _ |0 PERI:(DE-600)1494955-6
|a 10.1038/s41593-024-01827-9
|g Vol. 27, no. 12, p. 2278 - 2291
|n 12
|p 2278 - 2291
|t Nature neuroscience
|v 27
|x 1097-6256
|y 2024
856 4 _ |u https://pub.dzne.de/record/275838/files/DZNE-2025-00073_Restricted.pdf
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|a Deutsches Zentrum für Neurodegenerative Erkrankungen
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Marc 21