Home > Publications Database > Applying single-cell and single-nucleus genomics to studies of cellular heterogeneity and cell fate transitions in the nervous system. > print

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005     20250119000340.0
024 7 _ |a 10.1038/s41593-024-01827-9
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037 _ _ |a DZNE-2025-00073
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082 _ _ |a 610
100 1 _ |a Adameyko, Igor
|0 0000-0001-5471-0356
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245 _ _ |a Applying single-cell and single-nucleus genomics to studies of cellular heterogeneity and cell fate transitions in the nervous system.
260 _ _ |a New York, NY
|c 2024
|b Nature America
336 7 _ |a article
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520 _ _ |a Single-cell and single-nucleus genomic approaches can provide unbiased and multimodal insights. Here, we discuss what constitutes a molecular cell atlas and how to leverage single-cell omics data to generate hypotheses and gain insights into cell transitions in development and disease of the nervous system. We share points of reflection on what to consider during study design and implementation as well as limitations and pitfalls.
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650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Cell Differentiation: genetics
|2 MeSH
650 _ 2 |a Cell Nucleus: metabolism
|2 MeSH
650 _ 2 |a Cell Nucleus: genetics
|2 MeSH
650 _ 2 |a Genomics: methods
|2 MeSH
650 _ 2 |a Nervous System: cytology
|2 MeSH
650 _ 2 |a Nervous System: metabolism
|2 MeSH
650 _ 2 |a Single-Cell Analysis: methods
|2 MeSH
700 1 _ |a Bakken, Trygve
|0 0000-0003-3373-7386
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700 1 _ |a Bhaduri, Aparna
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700 1 _ |a Chhatbar, Chintan
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700 1 _ |a Filbin, Mariella G
|b 4
700 1 _ |a Gate, David
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700 1 _ |a Hochgerner, Hannah
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700 1 _ |a Kim, Chang Nam
|0 0000-0001-7921-4447
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700 1 _ |a Krull, Jordan
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700 1 _ |a La Manno, Gioele
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700 1 _ |a Li, Qingyun
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700 1 _ |a Linnarsson, Sten
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700 1 _ |a Ma, Qin
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700 1 _ |a Mayer, Christian
|0 0000-0003-3152-5574
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700 1 _ |a Menon, Vilas
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700 1 _ |a Nano, Patricia
|0 0000-0002-5507-2656
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700 1 _ |a Prinz, Marco
|0 0000-0002-0349-1955
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700 1 _ |a Quake, Steve
|b 17
700 1 _ |a Walsh, Christopher A
|0 0000-0002-0156-2238
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700 1 _ |a Yang, Jin
|b 19
700 1 _ |a Bayraktar, Omer Ali
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700 1 _ |a Gokce, Ozgun
|0 P:(DE-2719)9002754
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700 1 _ |a Habib, Naomi
|0 0000-0002-6049-2487
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700 1 _ |a Konopka, Genevieve
|0 0000-0002-3363-7302
|b 23
700 1 _ |a Liddelow, Shane A
|0 0000-0002-0840-1437
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700 1 _ |a Nowakowski, Tomasz J
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773 _ _ |a 10.1038/s41593-024-01827-9
|g Vol. 27, no. 12, p. 2278 - 2291
|0 PERI:(DE-600)1494955-6
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|p 2278 - 2291
|t Nature neuroscience
|v 27
|y 2024
|x 1097-6256
856 4 _ |u https://pub.dzne.de/record/275838/files/DZNE-2025-00073_Restricted.pdf
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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