%0 Journal Article
%A Liu, Feng-Tao
%A Lu, Jia-Ying
%A Li, Xin-Yi
%A Ge, Jing-Jie
%A Sun, Yi-Min
%A Yen, Tzu-Chen
%A Jiao, Fang-Yang
%A Chen, Ming-Jia
%A Zhao, Jun
%A Yao, Rui-Xin
%A Tang, Gan
%A Xu, Hao
%A Lan, Xiao-Li
%A Lu, Jie
%A Cui, Rui-Xue
%A Brendel, Matthias
%A Shi, Kuangyu
%A Guan, Yi-Hui
%A Rominger, Axel
%A Wang, Jian
%A Zuo, Chuan-Tao
%T Visual reading for [18F]Florzolotau Tau PET scans in progressive supranuclear palsy.
%J European journal of nuclear medicine and molecular imaging
%V 52
%N 2
%@ 1619-7070
%C Heidelberg [u.a.]
%I Springer-Verl.
%M DZNE-2025-00157
%P 586 - 598
%D 2025
%X The identification of tau accumulation within living brains holds significant potential in facilitating accurate diagnosis of progressive supranuclear palsy (PSP). While visual assessment is frequently employed, standardized methods for tau positron emission tomography (PET) specifically in PSP are absent. We aimed to develop a visual reading algorithm dedicated to the evaluation of [18F]Florzolotau PET in PSP.148 PSP and 30 healthy volunteers were divided into a development set (for the establishment of the reading rules; n = 89) and a testing set (for the validation of the reading rules; n = 89). For differential diagnosis, 55 α-synucleinopathies were additionally included into the testing set. The visual reading method was established by an experienced assessor (Reader 0) and was then validated by Reader 0 and two additional readers on regional and overall binary manners. A positive binding in both midbrain and globus pallidus/putamen regions was characterized as a PSP-like pattern, whereas any other pattern was classified as non-PSP-like.Reader 1 (94.4
%K Humans
%K Supranuclear Palsy, Progressive: diagnostic imaging
%K Supranuclear Palsy, Progressive: metabolism
%K Positron-Emission Tomography: methods
%K Male
%K Female
%K tau Proteins: metabolism
%K Aged
%K Middle Aged
%K Aniline Compounds
%K Case-Control Studies
%K Carbolines: pharmacokinetics
%K Radiopharmaceuticals: pharmacokinetics
%K Algorithms
%K Positron emission tomography (Other)
%K Progressive supranuclear palsy (Other)
%K Visual reading algorithm (Other)
%K [18F]Florzorotau (Other)
%K tau Proteins (NLM Chemicals)
%K Aniline Compounds (NLM Chemicals)
%K Carbolines (NLM Chemicals)
%K Radiopharmaceuticals (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39352424
%R 10.1007/s00259-024-06923-3
%U https://pub.dzne.de/record/275935