Journal Article

DZNE-2025-00157

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Visual reading for [18F]Florzolotau Tau PET scans in progressive supranuclear palsy.

Liu, F.-T. ; Lu, J.-Y. ; Li, X.-Y. ; Ge, J.-J. ; Sun, Y.-M. ; Yen, T.-C. ; Jiao, F.-Y. ; Chen, M.-J. ; Zhao, J. ; Yao, R.-X. ; Tang, G. ; Xu, H. ; Lan, X.-L. ; Lu, J. ; Cui, R.-X. ; Brendel, M.DZNE* ; Shi, K. ; Guan, Y.-H. ; Rominger, A. ; Wang, J. ; Zuo, C.-T. ; Initiative, P. S. P. N. (Collaboration Author)

2025
Springer-Verl. Heidelberg [u.a.]

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Please use a persistent id in citations: doi:10.1007/s00259-024-06923-3

Abstract: The identification of tau accumulation within living brains holds significant potential in facilitating accurate diagnosis of progressive supranuclear palsy (PSP). While visual assessment is frequently employed, standardized methods for tau positron emission tomography (PET) specifically in PSP are absent. We aimed to develop a visual reading algorithm dedicated to the evaluation of [18F]Florzolotau PET in PSP.148 PSP and 30 healthy volunteers were divided into a development set (for the establishment of the reading rules; n = 89) and a testing set (for the validation of the reading rules; n = 89). For differential diagnosis, 55 α-synucleinopathies were additionally included into the testing set. The visual reading method was established by an experienced assessor (Reader 0) and was then validated by Reader 0 and two additional readers on regional and overall binary manners. A positive binding in both midbrain and globus pallidus/putamen regions was characterized as a PSP-like pattern, whereas any other pattern was classified as non-PSP-like.Reader 1 (94.4%) and Reader 2 (93.8%) showed excellent agreement for the overall binary determination against Reader 0. The regional binary determinations of midbrain and globus pallidus/putamen showed excellent agreement among readers (kappa > 0.80). The overall binary evaluation demonstrated reproducibility of 86.1%, 94.4% and 77.8% for three readers. The visual reading algorithm showed high agreement with regional standardized uptake value ratios and clinical diagnoses.Through the application of the suggested visual reading algorithm, [18F]Florzorotau PET imaging demonstrated a robust performance for the imaging diagnosis of PSP.

Keyword(s): Humans (MeSH) ; Supranuclear Palsy, Progressive: diagnostic imaging (MeSH) ; Supranuclear Palsy, Progressive: metabolism (MeSH) ; Positron-Emission Tomography: methods (MeSH) ; Male (MeSH) ; Female (MeSH) ; tau Proteins: metabolism (MeSH) ; Aged (MeSH) ; Middle Aged (MeSH) ; Aniline Compounds (MeSH) ; Case-Control Studies (MeSH) ; Carbolines: pharmacokinetics (MeSH) ; Radiopharmaceuticals: pharmacokinetics (MeSH) ; Algorithms (MeSH) ; Positron emission tomography ; Progressive supranuclear palsy ; Visual reading algorithm ; [18F]Florzorotau ; tau Proteins ; Aniline Compounds ; Carbolines ; Radiopharmaceuticals

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Contributing Institute(s):

1. Molecular Neurodegeneration (AG Haass)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Appears in the scientific report 2025

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Springer ; DEAL Springer ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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