TY  - JOUR
AU  - Liu, Feng-Tao
AU  - Lu, Jia-Ying
AU  - Li, Xin-Yi
AU  - Ge, Jing-Jie
AU  - Sun, Yi-Min
AU  - Yen, Tzu-Chen
AU  - Jiao, Fang-Yang
AU  - Chen, Ming-Jia
AU  - Zhao, Jun
AU  - Yao, Rui-Xin
AU  - Tang, Gan
AU  - Xu, Hao
AU  - Lan, Xiao-Li
AU  - Lu, Jie
AU  - Cui, Rui-Xue
AU  - Brendel, Matthias
AU  - Shi, Kuangyu
AU  - Guan, Yi-Hui
AU  - Rominger, Axel
AU  - Wang, Jian
AU  - Zuo, Chuan-Tao
TI  - Visual reading for [18F]Florzolotau Tau PET scans in progressive supranuclear palsy.
JO  - European journal of nuclear medicine and molecular imaging
VL  - 52
IS  - 2
SN  - 1619-7070
CY  - Heidelberg [u.a.]
PB  - Springer-Verl.
M1  - DZNE-2025-00157
SP  - 586 - 598
PY  - 2025
AB  - The identification of tau accumulation within living brains holds significant potential in facilitating accurate diagnosis of progressive supranuclear palsy (PSP). While visual assessment is frequently employed, standardized methods for tau positron emission tomography (PET) specifically in PSP are absent. We aimed to develop a visual reading algorithm dedicated to the evaluation of [18F]Florzolotau PET in PSP.148 PSP and 30 healthy volunteers were divided into a development set (for the establishment of the reading rules; n = 89) and a testing set (for the validation of the reading rules; n = 89). For differential diagnosis, 55 α-synucleinopathies were additionally included into the testing set. The visual reading method was established by an experienced assessor (Reader 0) and was then validated by Reader 0 and two additional readers on regional and overall binary manners. A positive binding in both midbrain and globus pallidus/putamen regions was characterized as a PSP-like pattern, whereas any other pattern was classified as non-PSP-like.Reader 1 (94.4
KW  - Humans
KW  - Supranuclear Palsy, Progressive: diagnostic imaging
KW  - Supranuclear Palsy, Progressive: metabolism
KW  - Positron-Emission Tomography: methods
KW  - Male
KW  - Female
KW  - tau Proteins: metabolism
KW  - Aged
KW  - Middle Aged
KW  - Aniline Compounds
KW  - Case-Control Studies
KW  - Carbolines: pharmacokinetics
KW  - Radiopharmaceuticals: pharmacokinetics
KW  - Algorithms
KW  - Positron emission tomography (Other)
KW  - Progressive supranuclear palsy (Other)
KW  - Visual reading algorithm (Other)
KW  - [18F]Florzorotau (Other)
KW  - tau Proteins (NLM Chemicals)
KW  - Aniline Compounds (NLM Chemicals)
KW  - Carbolines (NLM Chemicals)
KW  - Radiopharmaceuticals (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:39352424
DO  - DOI:10.1007/s00259-024-06923-3
UR  - https://pub.dzne.de/record/275935
ER  -