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@ARTICLE{Liu:275935,
      author       = {Liu, Feng-Tao and Lu, Jia-Ying and Li, Xin-Yi and Ge,
                      Jing-Jie and Sun, Yi-Min and Yen, Tzu-Chen and Jiao,
                      Fang-Yang and Chen, Ming-Jia and Zhao, Jun and Yao, Rui-Xin
                      and Tang, Gan and Xu, Hao and Lan, Xiao-Li and Lu, Jie and
                      Cui, Rui-Xue and Brendel, Matthias and Shi, Kuangyu and
                      Guan, Yi-Hui and Rominger, Axel and Wang, Jian and Zuo,
                      Chuan-Tao},
      collaboration = {Initiative, Progressive Supranuclear Palsy Neuroimage},
      title        = {{V}isual reading for [18{F}]{F}lorzolotau {T}au {PET} scans
                      in progressive supranuclear palsy.},
      journal      = {European journal of nuclear medicine and molecular imaging},
      volume       = {52},
      number       = {2},
      issn         = {1619-7070},
      address      = {Heidelberg [u.a.]},
      publisher    = {Springer-Verl.},
      reportid     = {DZNE-2025-00157},
      pages        = {586 - 598},
      year         = {2025},
      abstract     = {The identification of tau accumulation within living brains
                      holds significant potential in facilitating accurate
                      diagnosis of progressive supranuclear palsy (PSP). While
                      visual assessment is frequently employed, standardized
                      methods for tau positron emission tomography (PET)
                      specifically in PSP are absent. We aimed to develop a visual
                      reading algorithm dedicated to the evaluation of
                      [18F]Florzolotau PET in PSP.148 PSP and 30 healthy
                      volunteers were divided into a development set (for the
                      establishment of the reading rules; n = 89) and a testing
                      set (for the validation of the reading rules; n = 89). For
                      differential diagnosis, 55 α-synucleinopathies were
                      additionally included into the testing set. The visual
                      reading method was established by an experienced assessor
                      (Reader 0) and was then validated by Reader 0 and two
                      additional readers on regional and overall binary manners. A
                      positive binding in both midbrain and globus
                      pallidus/putamen regions was characterized as a PSP-like
                      pattern, whereas any other pattern was classified as
                      non-PSP-like.Reader 1 $(94.4\%)$ and Reader 2 $(93.8\%)$
                      showed excellent agreement for the overall binary
                      determination against Reader 0. The regional binary
                      determinations of midbrain and globus pallidus/putamen
                      showed excellent agreement among readers (kappa > 0.80). The
                      overall binary evaluation demonstrated reproducibility of
                      $86.1\%,$ $94.4\%$ and $77.8\%$ for three readers. The
                      visual reading algorithm showed high agreement with regional
                      standardized uptake value ratios and clinical
                      diagnoses.Through the application of the suggested visual
                      reading algorithm, [18F]Florzorotau PET imaging demonstrated
                      a robust performance for the imaging diagnosis of PSP.},
      keywords     = {Humans / Supranuclear Palsy, Progressive: diagnostic
                      imaging / Supranuclear Palsy, Progressive: metabolism /
                      Positron-Emission Tomography: methods / Male / Female / tau
                      Proteins: metabolism / Aged / Middle Aged / Aniline
                      Compounds / Case-Control Studies / Carbolines:
                      pharmacokinetics / Radiopharmaceuticals: pharmacokinetics /
                      Algorithms / Positron emission tomography (Other) /
                      Progressive supranuclear palsy (Other) / Visual reading
                      algorithm (Other) / [18F]Florzorotau (Other) / tau Proteins
                      (NLM Chemicals) / Aniline Compounds (NLM Chemicals) /
                      Carbolines (NLM Chemicals) / Radiopharmaceuticals (NLM
                      Chemicals)},
      cin          = {AG Haass},
      ddc          = {610},
      cid          = {I:(DE-2719)1110007},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39352424},
      doi          = {10.1007/s00259-024-06923-3},
      url          = {https://pub.dzne.de/record/275935},
}