%0 Journal Article
%A Sampatakakis, Stefanos N
%A Mourtzi, Niki
%A Charisis, Sokratis
%A Mamalaki, Eirini
%A Ntanasi, Eva
%A Hatzimanolis, Alex
%A Ramirez, Alfredo
%A Lambert, Jean-Charles
%A Yannakoulia, Mary
%A Kosmidis, Mary H
%A Dardiotis, Efthimios
%A Hadjigeorgiou, Georgios
%A Megalou, Maria
%A Sakka, Paraskevi
%A Scarmeas, Nikolaos
%T Walking time and genetic predisposition for Alzheimer's disease: Results from the HELIAD study.
%J The clinical neuropsychologist
%V 39
%N 1
%@ 0920-1637
%C Abingdon
%I Routledge, Taylor Francis Group
%M DZNE-2025-00208
%P 83 - 99
%D 2025
%X Objective: Our study aimed to explore whether physical condition might affect the association between genetic predisposition for Alzheimer's Disease (AD) and AD incidence. Methods: The sample of participants consisted of 561 community-dwelling adults over 64 years old, without baseline dementia (508 cognitively normal and 53 with mild cognitive impairment), deriving from the HELIAD, an ongoing longitudinal study with follow-up evaluations every 3 years. Physical condition was assessed at baseline through walking time (WT), while a Polygenic Risk Score for late onset AD (PRS-AD) was used to estimate genetic predisposition. The association between WT and PRS-AD with AD incidence was evaluated with Cox proportional hazard models adjusted for age, sex, education years, global cognition score and APOE ε-4 genotype. Then, the association between WT and AD incidence was investigated after stratifying participants by low and high PRS-AD. Finally, we examined the association between PRS-AD and AD incidence after stratifying participants by WT. Results: Both WT and PRS-AD were connected with increased AD incidence (p < 0.05), after adjustments. In stratified analyses, in the slow WT group participants with a greater genetic risk had a 2.5-fold higher risk of developing AD compared to participants with lower genetic risk (p = 0.047). No association was observed in the fast WT group or when participants were stratified based on PRS-AD. Conclusions: Genetic predisposition for AD is more closely related to AD incidence in the group of older adults with slow WT. Hence, physical condition might be a modifier in the relationship of genetic predisposition with AD incidence.
%K Humans
%K Alzheimer Disease: genetics
%K Alzheimer Disease: epidemiology
%K Female
%K Male
%K Aged
%K Genetic Predisposition to Disease
%K Longitudinal Studies
%K Incidence
%K Cognitive Dysfunction: genetics
%K Cognitive Dysfunction: physiopathology
%K Aged, 80 and over
%K Walking: physiology
%K Alzheimer’s disease (Other)
%K genetic predisposition (Other)
%K physical condition (Other)
%K polygenic risk (Other)
%K walking time (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:38741352
%R 10.1080/13854046.2024.2344869
%U https://pub.dzne.de/record/276127