Journal Article

DZNE-2025-00208

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Walking time and genetic predisposition for Alzheimer's disease: Results from the HELIAD study.

Sampatakakis, S. N. ; Mourtzi, N. ; Charisis, S. ; Mamalaki, E. ; Ntanasi, E. ; Hatzimanolis, A. ; Ramirez, A.DZNE* ; Lambert, J.-C. ; Yannakoulia, M. ; Kosmidis, M. H. ; Dardiotis, E. ; Hadjigeorgiou, G. ; Megalou, M. ; Sakka, P. ; Scarmeas, N.

2025
Routledge, Taylor Francis Group Abingdon

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Please use a persistent id in citations: doi:10.1080/13854046.2024.2344869

Abstract: Objective: Our study aimed to explore whether physical condition might affect the association between genetic predisposition for Alzheimer's Disease (AD) and AD incidence. Methods: The sample of participants consisted of 561 community-dwelling adults over 64 years old, without baseline dementia (508 cognitively normal and 53 with mild cognitive impairment), deriving from the HELIAD, an ongoing longitudinal study with follow-up evaluations every 3 years. Physical condition was assessed at baseline through walking time (WT), while a Polygenic Risk Score for late onset AD (PRS-AD) was used to estimate genetic predisposition. The association between WT and PRS-AD with AD incidence was evaluated with Cox proportional hazard models adjusted for age, sex, education years, global cognition score and APOE ε-4 genotype. Then, the association between WT and AD incidence was investigated after stratifying participants by low and high PRS-AD. Finally, we examined the association between PRS-AD and AD incidence after stratifying participants by WT. Results: Both WT and PRS-AD were connected with increased AD incidence (p < 0.05), after adjustments. In stratified analyses, in the slow WT group participants with a greater genetic risk had a 2.5-fold higher risk of developing AD compared to participants with lower genetic risk (p = 0.047). No association was observed in the fast WT group or when participants were stratified based on PRS-AD. Conclusions: Genetic predisposition for AD is more closely related to AD incidence in the group of older adults with slow WT. Hence, physical condition might be a modifier in the relationship of genetic predisposition with AD incidence.

Keyword(s): Humans (MeSH) ; Alzheimer Disease: genetics (MeSH) ; Alzheimer Disease: epidemiology (MeSH) ; Female (MeSH) ; Male (MeSH) ; Aged (MeSH) ; Genetic Predisposition to Disease (MeSH) ; Longitudinal Studies (MeSH) ; Incidence (MeSH) ; Cognitive Dysfunction: genetics (MeSH) ; Cognitive Dysfunction: physiopathology (MeSH) ; Aged, 80 and over (MeSH) ; Walking: physiology (MeSH) ; Alzheimer’s disease ; genetic predisposition ; physical condition ; polygenic risk ; walking time

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Contributing Institute(s):

1. Patient Studies (Bonn) (Patient Studies (Bonn))

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2025

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Social and Behavioral Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Social Sciences Citation Index ; Web of Science Core Collection

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