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000276127 041__ $$aEnglish
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000276127 1001_ $$aSampatakakis, Stefanos N$$b0
000276127 245__ $$aWalking time and genetic predisposition for Alzheimer's disease: Results from the HELIAD study.
000276127 260__ $$aAbingdon$$bRoutledge, Taylor Francis Group$$c2025
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000276127 520__ $$aObjective: Our study aimed to explore whether physical condition might affect the association between genetic predisposition for Alzheimer's Disease (AD) and AD incidence. Methods: The sample of participants consisted of 561 community-dwelling adults over 64 years old, without baseline dementia (508 cognitively normal and 53 with mild cognitive impairment), deriving from the HELIAD, an ongoing longitudinal study with follow-up evaluations every 3 years. Physical condition was assessed at baseline through walking time (WT), while a Polygenic Risk Score for late onset AD (PRS-AD) was used to estimate genetic predisposition. The association between WT and PRS-AD with AD incidence was evaluated with Cox proportional hazard models adjusted for age, sex, education years, global cognition score and APOE ε-4 genotype. Then, the association between WT and AD incidence was investigated after stratifying participants by low and high PRS-AD. Finally, we examined the association between PRS-AD and AD incidence after stratifying participants by WT. Results: Both WT and PRS-AD were connected with increased AD incidence (p < 0.05), after adjustments. In stratified analyses, in the slow WT group participants with a greater genetic risk had a 2.5-fold higher risk of developing AD compared to participants with lower genetic risk (p = 0.047). No association was observed in the fast WT group or when participants were stratified based on PRS-AD. Conclusions: Genetic predisposition for AD is more closely related to AD incidence in the group of older adults with slow WT. Hence, physical condition might be a modifier in the relationship of genetic predisposition with AD incidence.
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000276127 650_7 $$2Other$$aAlzheimer’s disease
000276127 650_7 $$2Other$$agenetic predisposition
000276127 650_7 $$2Other$$aphysical condition
000276127 650_7 $$2Other$$apolygenic risk
000276127 650_7 $$2Other$$awalking time
000276127 650_2 $$2MeSH$$aHumans
000276127 650_2 $$2MeSH$$aAlzheimer Disease: genetics
000276127 650_2 $$2MeSH$$aAlzheimer Disease: epidemiology
000276127 650_2 $$2MeSH$$aFemale
000276127 650_2 $$2MeSH$$aMale
000276127 650_2 $$2MeSH$$aAged
000276127 650_2 $$2MeSH$$aGenetic Predisposition to Disease
000276127 650_2 $$2MeSH$$aLongitudinal Studies
000276127 650_2 $$2MeSH$$aIncidence
000276127 650_2 $$2MeSH$$aCognitive Dysfunction: genetics
000276127 650_2 $$2MeSH$$aCognitive Dysfunction: physiopathology
000276127 650_2 $$2MeSH$$aAged, 80 and over
000276127 650_2 $$2MeSH$$aWalking: physiology
000276127 7001_ $$aMourtzi, Niki$$b1
000276127 7001_ $$aCharisis, Sokratis$$b2
000276127 7001_ $$aMamalaki, Eirini$$b3
000276127 7001_ $$aNtanasi, Eva$$b4
000276127 7001_ $$aHatzimanolis, Alex$$b5
000276127 7001_ $$0P:(DE-2719)2812825$$aRamirez, Alfredo$$b6$$udzne
000276127 7001_ $$aLambert, Jean-Charles$$b7
000276127 7001_ $$aYannakoulia, Mary$$b8
000276127 7001_ $$aKosmidis, Mary H$$b9
000276127 7001_ $$aDardiotis, Efthimios$$b10
000276127 7001_ $$aHadjigeorgiou, Georgios$$b11
000276127 7001_ $$aMegalou, Maria$$b12
000276127 7001_ $$aSakka, Paraskevi$$b13
000276127 7001_ $$aScarmeas, Nikolaos$$b14
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