TY  - JOUR
AU  - Sampatakakis, Stefanos N
AU  - Mourtzi, Niki
AU  - Charisis, Sokratis
AU  - Mamalaki, Eirini
AU  - Ntanasi, Eva
AU  - Hatzimanolis, Alex
AU  - Ramirez, Alfredo
AU  - Lambert, Jean-Charles
AU  - Yannakoulia, Mary
AU  - Kosmidis, Mary H
AU  - Dardiotis, Efthimios
AU  - Hadjigeorgiou, Georgios
AU  - Megalou, Maria
AU  - Sakka, Paraskevi
AU  - Scarmeas, Nikolaos
TI  - Walking time and genetic predisposition for Alzheimer's disease: Results from the HELIAD study.
JO  - The clinical neuropsychologist
VL  - 39
IS  - 1
SN  - 0920-1637
CY  - Abingdon
PB  - Routledge, Taylor Francis Group
M1  - DZNE-2025-00208
SP  - 83 - 99
PY  - 2025
AB  - Objective: Our study aimed to explore whether physical condition might affect the association between genetic predisposition for Alzheimer's Disease (AD) and AD incidence. Methods: The sample of participants consisted of 561 community-dwelling adults over 64 years old, without baseline dementia (508 cognitively normal and 53 with mild cognitive impairment), deriving from the HELIAD, an ongoing longitudinal study with follow-up evaluations every 3 years. Physical condition was assessed at baseline through walking time (WT), while a Polygenic Risk Score for late onset AD (PRS-AD) was used to estimate genetic predisposition. The association between WT and PRS-AD with AD incidence was evaluated with Cox proportional hazard models adjusted for age, sex, education years, global cognition score and APOE ε-4 genotype. Then, the association between WT and AD incidence was investigated after stratifying participants by low and high PRS-AD. Finally, we examined the association between PRS-AD and AD incidence after stratifying participants by WT. Results: Both WT and PRS-AD were connected with increased AD incidence (p < 0.05), after adjustments. In stratified analyses, in the slow WT group participants with a greater genetic risk had a 2.5-fold higher risk of developing AD compared to participants with lower genetic risk (p = 0.047). No association was observed in the fast WT group or when participants were stratified based on PRS-AD. Conclusions: Genetic predisposition for AD is more closely related to AD incidence in the group of older adults with slow WT. Hence, physical condition might be a modifier in the relationship of genetic predisposition with AD incidence.
KW  - Humans
KW  - Alzheimer Disease: genetics
KW  - Alzheimer Disease: epidemiology
KW  - Female
KW  - Male
KW  - Aged
KW  - Genetic Predisposition to Disease
KW  - Longitudinal Studies
KW  - Incidence
KW  - Cognitive Dysfunction: genetics
KW  - Cognitive Dysfunction: physiopathology
KW  - Aged, 80 and over
KW  - Walking: physiology
KW  - Alzheimer’s disease (Other)
KW  - genetic predisposition (Other)
KW  - physical condition (Other)
KW  - polygenic risk (Other)
KW  - walking time (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:38741352
DO  - DOI:10.1080/13854046.2024.2344869
UR  - https://pub.dzne.de/record/276127
ER  -