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@ARTICLE{Sampatakakis:276127,
      author       = {Sampatakakis, Stefanos N and Mourtzi, Niki and Charisis,
                      Sokratis and Mamalaki, Eirini and Ntanasi, Eva and
                      Hatzimanolis, Alex and Ramirez, Alfredo and Lambert,
                      Jean-Charles and Yannakoulia, Mary and Kosmidis, Mary H and
                      Dardiotis, Efthimios and Hadjigeorgiou, Georgios and
                      Megalou, Maria and Sakka, Paraskevi and Scarmeas, Nikolaos},
      title        = {{W}alking time and genetic predisposition for {A}lzheimer's
                      disease: {R}esults from the {HELIAD} study.},
      journal      = {The clinical neuropsychologist},
      volume       = {39},
      number       = {1},
      issn         = {0920-1637},
      address      = {Abingdon},
      publisher    = {Routledge, Taylor Francis Group},
      reportid     = {DZNE-2025-00208},
      pages        = {83 - 99},
      year         = {2025},
      abstract     = {Objective: Our study aimed to explore whether physical
                      condition might affect the association between genetic
                      predisposition for Alzheimer's Disease (AD) and AD
                      incidence. Methods: The sample of participants consisted of
                      561 community-dwelling adults over 64 years old, without
                      baseline dementia (508 cognitively normal and 53 with mild
                      cognitive impairment), deriving from the HELIAD, an ongoing
                      longitudinal study with follow-up evaluations every 3 years.
                      Physical condition was assessed at baseline through walking
                      time (WT), while a Polygenic Risk Score for late onset AD
                      (PRS-AD) was used to estimate genetic predisposition. The
                      association between WT and PRS-AD with AD incidence was
                      evaluated with Cox proportional hazard models adjusted for
                      age, sex, education years, global cognition score and APOE
                      ε-4 genotype. Then, the association between WT and AD
                      incidence was investigated after stratifying participants by
                      low and high PRS-AD. Finally, we examined the association
                      between PRS-AD and AD incidence after stratifying
                      participants by WT. Results: Both WT and PRS-AD were
                      connected with increased AD incidence (p < 0.05), after
                      adjustments. In stratified analyses, in the slow WT group
                      participants with a greater genetic risk had a 2.5-fold
                      higher risk of developing AD compared to participants with
                      lower genetic risk (p = 0.047). No association was observed
                      in the fast WT group or when participants were stratified
                      based on PRS-AD. Conclusions: Genetic predisposition for AD
                      is more closely related to AD incidence in the group of
                      older adults with slow WT. Hence, physical condition might
                      be a modifier in the relationship of genetic predisposition
                      with AD incidence.},
      keywords     = {Humans / Alzheimer Disease: genetics / Alzheimer Disease:
                      epidemiology / Female / Male / Aged / Genetic Predisposition
                      to Disease / Longitudinal Studies / Incidence / Cognitive
                      Dysfunction: genetics / Cognitive Dysfunction:
                      physiopathology / Aged, 80 and over / Walking: physiology /
                      Alzheimer’s disease (Other) / genetic predisposition
                      (Other) / physical condition (Other) / polygenic risk
                      (Other) / walking time (Other)},
      cin          = {Patient Studies (Bonn)},
      ddc          = {610},
      cid          = {I:(DE-2719)1011101},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:38741352},
      doi          = {10.1080/13854046.2024.2344869},
      url          = {https://pub.dzne.de/record/276127},
}