Journal Article (Review Article)

DZNE-2025-00334

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Unveiling the hippocampal subfield changes across the Alzheimer's disease continuum: a systematic review of neuroimaging studies.

Zilioli, A. ; Pancaldi, B. ; Baumeister, H.DZNE* ; Busi, G. ; Misirocchi, F. ; Mutti, C. ; Florindo, I. ; Morelli, N. ; Mohanty, R. ; Berron, D.DZNE* ; Westman, E. ; Spallazzi, M.

2025
Springer New York, NY [u.a.]

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Please use a persistent id in citations: doi:10.1007/s11682-024-00952-0

Abstract: Studies exploring the hippocampal subfield atrophy in Alzheimer's disease (AD) have shown contradictory results. This review aims to disentangle such heterogeneity by investigating the dynamic changes of hippocampal subfields across the AD continuum. We systematically searched the PubMed and EMBASE databases for case-control studies. Selected studies included investigations of biomarker-based amyloid status and reported data on hippocampal subfield atrophy using advanced MRI techniques. Twelve studies were included. Despite high heterogeneity, a distinguishable pattern of vulnerability of hippocampal subfields can be recognized from the cognitively unimpaired phase to the dementia stage, shedding light on hippocampal changes with disease progression. Consistent findings revealed atrophy in the subiculum and presubiculum, along with a potential increase in volume in the cornu ammonis (CA) among the cognitively unimpaired group, a feature not observed in patients experiencing subjective cognitive decline. Atrophy in the subiculum, presubiculum, CA 1-4, and the dentate gyrus characterized the mild cognitive impairment stage, with a more pronounced severity in the progression to dementia.

Keyword(s): Alzheimer Disease: diagnostic imaging (MeSH) ; Alzheimer Disease: pathology (MeSH) ; Humans (MeSH) ; Hippocampus: pathology (MeSH) ; Hippocampus: diagnostic imaging (MeSH) ; Neuroimaging: methods (MeSH) ; Atrophy (MeSH) ; Disease Progression (MeSH) ; Magnetic Resonance Imaging: methods (MeSH) ; Cognitive Dysfunction: diagnostic imaging (MeSH) ; Alzheimer’s disease continuum ; Hippocampal subfields ; Hippocampal volume and surface

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Contributing Institute(s):

1. Clinical Cognitive Neuroscience (AG Berron)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2025

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Springer ; DEAL Springer ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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