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@ARTICLE{Reese:276826,
      author       = {Reese, René and Koeglsperger, Thomas and Schrader,
                      Christoph and Tönges, Lars and Deuschl, Günther and Kühn,
                      Andrea and Krack, Paul and Schnitzler, Alfons and Storch,
                      Alexander and Trenkwalder, Claudia and Höglinger, Günter
                      U},
      collaboration = {Group, German Parkinson‘s Guideline},
      title        = {{I}nvasive therapies for {P}arkinson's disease: an adapted
                      excerpt from the guidelines of the {G}erman {S}ociety of
                      {N}eurology.},
      journal      = {Journal of neurology},
      volume       = {272},
      number       = {3},
      issn         = {0367-004X},
      address      = {[Darmstadt]},
      publisher    = {Steinkopff},
      reportid     = {DZNE-2025-00339},
      pages        = {219},
      year         = {2025},
      abstract     = {Parkinson's disease (PD) is characterized by hypokinetic
                      motor symptoms, tremor, and various non-motor symptoms with
                      frequent fluctuations of symptoms in advanced disease
                      stages. Invasive therapies, such as deep brain stimulation
                      (DBS), ablative therapies, and continuous subcutaneous or
                      intrajejunal delivery of dopaminergic drugs via pump
                      therapies are available for the management of this complex
                      motor symptomatology and may also impact non-motor symptoms.
                      The recent update of the clinical guideline on PD by the
                      German Neurological Society (Deutsche Gesellschaft für
                      Neurologie e.V.; DGN) offers clear guidance on the
                      indications and applications of these treatment options.The
                      guideline committee formulated diagnostic questions for
                      invasive therapies and structured them according to the
                      PICOS framework
                      (Population-Intervention-Comparisons-Outcome-Studies). A
                      systematic literature review was conducted. Questions were
                      addressed using the findings from the literature review and
                      consented by the guideline committee.Specific
                      recommendations are given regarding (i) the optimal timing
                      for starting invasive therapies, (ii) the application of
                      DBS, (iii) the use of pump therapies in advanced PD, (iv)
                      the indications for ablative procedures, and (iv) selecting
                      the most appropriate therapy according to individual patient
                      characteristics.This review is an adapted excerpt of the
                      chapters on the use of invasive therapies in PD of the novel
                      German guideline on PD. Clear recommendations on the use of
                      treatment options for advanced PD are provided.},
      subtyp        = {Review Article},
      keywords     = {Humans / Parkinson Disease: therapy / Deep Brain
                      Stimulation: standards / Neurology: standards / Neurology:
                      methods / Germany / Practice Guidelines as Topic: standards
                      / Societies, Medical: standards / Ablation (Other) / Deep
                      brain stimulation (DBS) (Other) / Invasive therapies (Other)
                      / Parkinson’s disease (Other) / Pump therapy (Other)},
      cin          = {Clinical Research (Munich) / AG Storch},
      ddc          = {610},
      cid          = {I:(DE-2719)1111015 / I:(DE-2719)5000014},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39985674},
      pmc          = {pmc:PMC11846738},
      doi          = {10.1007/s00415-025-12915-6},
      url          = {https://pub.dzne.de/record/276826},
}