Journal Article (Review Article)

DZNE-2025-00339

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Invasive therapies for Parkinson's disease: an adapted excerpt from the guidelines of the German Society of Neurology.

Reese, R. ; Koeglsperger, T. (First author)DZNE* ; Schrader, C. ; Tönges, L. ; Deuschl, G. ; Kühn, A.Extern* ; Krack, P. ; Schnitzler, A. ; Storch, A.DZNE* ; Trenkwalder, C. ; Höglinger, G. U.DZNE* ; Group, G. P. G. (Collaboration Author)

2025
Steinkopff [Darmstadt]

This record in other databases:  

Please use a persistent id in citations: doi:10.1007/s00415-025-12915-6

Abstract: Parkinson's disease (PD) is characterized by hypokinetic motor symptoms, tremor, and various non-motor symptoms with frequent fluctuations of symptoms in advanced disease stages. Invasive therapies, such as deep brain stimulation (DBS), ablative therapies, and continuous subcutaneous or intrajejunal delivery of dopaminergic drugs via pump therapies are available for the management of this complex motor symptomatology and may also impact non-motor symptoms. The recent update of the clinical guideline on PD by the German Neurological Society (Deutsche Gesellschaft für Neurologie e.V.; DGN) offers clear guidance on the indications and applications of these treatment options.The guideline committee formulated diagnostic questions for invasive therapies and structured them according to the PICOS framework (Population-Intervention-Comparisons-Outcome-Studies). A systematic literature review was conducted. Questions were addressed using the findings from the literature review and consented by the guideline committee.Specific recommendations are given regarding (i) the optimal timing for starting invasive therapies, (ii) the application of DBS, (iii) the use of pump therapies in advanced PD, (iv) the indications for ablative procedures, and (iv) selecting the most appropriate therapy according to individual patient characteristics.This review is an adapted excerpt of the chapters on the use of invasive therapies in PD of the novel German guideline on PD. Clear recommendations on the use of treatment options for advanced PD are provided.

Keyword(s): Humans (MeSH) ; Parkinson Disease: therapy (MeSH) ; Deep Brain Stimulation: standards (MeSH) ; Neurology: standards (MeSH) ; Neurology: methods (MeSH) ; Germany (MeSH) ; Practice Guidelines as Topic: standards (MeSH) ; Societies, Medical: standards (MeSH) ; Ablation ; Deep brain stimulation (DBS) ; Invasive therapies ; Parkinson’s disease ; Pump therapy

---

Contributing Institute(s):

1. Clinical Research (Munich) (Clinical Research (Munich))
2. Non-Motor Symptoms in Parkinson's disease (AG Storch)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2025

---

Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Springer ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---