%0 Journal Article
%A Abu-Rumeileh, Samir
%A Scholle, Leila
%A Mensch, Alexander
%A Großkopf, Henning
%A Ratti, Antonia
%A Kölsch, Anna
%A Stoltenburg-Didinger, Gisela
%A Conrad, Julian
%A De Gobbi, Anna
%A Barba, Lorenzo
%A Steinacker, Petra
%A Klafki, Hans-Wolfgang
%A Oeckl, Patrick
%A Halbgebauer, Steffen
%A Stapf, Caroline
%A Posa, Andreas
%A Kendzierski, Thomas
%A Silani, Vincenzo
%A Hausner, Lucrezia
%A Ticozzi, Nicola
%A Froelich, Lutz
%A Weishaupt, Jochen Hans
%A Verde, Federico
%A Otto, Markus
%T Phosphorylated tau 181 and 217 are elevated in serum and muscle of patients with amyotrophic lateral sclerosis.
%J Nature Communications
%V 16
%N 1
%@ 2041-1723
%C [London]
%I Springer Nature
%M DZNE-2025-00412
%P 2019
%D 2025
%X Blood phosphorylated (p)-tau 181 and p-tau 217 have been proposed as accurate biomarkers of Alzheimer's disease (AD) pathology. However, blood p-tau 181 is also elevated in amyotrophic lateral sclerosis (ALS) without a clearly identified source. We measured serum p-tau 181 and p-tau 217 in a multicentre cohort of ALS (n = 152), AD (n = 111) cases and disease controls (n = 99) recruited from four different centres. Further, we investigated the existence of both p-tau species using immunohistochemistry (IHC) and mass spectrometry (MS) in muscle biopsies of ALS cases (IHC: n = 13, MS: n = 5) and disease controls (IHC: n = 14, MS: n = 5) from one cohort. Serum p-tau 181 and p-tau 217 were higher in AD and ALS patients compared to disease controls. IHC and MS analyses revealed the presence of p-tau 181 and 217 in muscle biopsies from both ALS cases and disease controls, with ALS samples showing increased p-tau reactivity in atrophic muscle fibres. Blood p-tau species could potentially be used to diagnose both ALS and AD.
%K Humans
%K Amyotrophic Lateral Sclerosis: blood
%K Amyotrophic Lateral Sclerosis: metabolism
%K Amyotrophic Lateral Sclerosis: pathology
%K tau Proteins: metabolism
%K tau Proteins: blood
%K Male
%K Female
%K Middle Aged
%K Aged
%K Phosphorylation
%K Biomarkers: blood
%K Alzheimer Disease: blood
%K Alzheimer Disease: metabolism
%K Alzheimer Disease: pathology
%K Alzheimer Disease: diagnosis
%K Muscle, Skeletal: metabolism
%K Muscle, Skeletal: pathology
%K Case-Control Studies
%K Biopsy
%K Aged, 80 and over
%K Adult
%K Cohort Studies
%K tau Proteins (NLM Chemicals)
%K Biomarkers (NLM Chemicals)
%K MAPT protein, human (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40044663
%2 pmc:PMC11882981
%R 10.1038/s41467-025-57144-7
%U https://pub.dzne.de/record/277429