Journal Article

DZNE-2025-00412

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Phosphorylated tau 181 and 217 are elevated in serum and muscle of patients with amyotrophic lateral sclerosis.

Abu-Rumeileh, S. ; Scholle, L. ; Mensch, A. ; Großkopf, H. ; Ratti, A. ; Kölsch, A. ; Stoltenburg-Didinger, G. ; Conrad, J. ; De Gobbi, A. ; Barba, L. ; Steinacker, P. ; Klafki, H.-W. ; Oeckl, P.DZNE* ; Halbgebauer, S.DZNE* ; Stapf, C. ; Posa, A. ; Kendzierski, T. ; Silani, V. ; Hausner, L. ; Ticozzi, N. ; Froelich, L. ; Weishaupt, J. H. ; Verde, F. ; Otto, M.

2025
Springer Nature [London]

This record in other databases:    

Please use a persistent id in citations: doi:10.1038/s41467-025-57144-7

Abstract: Blood phosphorylated (p)-tau 181 and p-tau 217 have been proposed as accurate biomarkers of Alzheimer's disease (AD) pathology. However, blood p-tau 181 is also elevated in amyotrophic lateral sclerosis (ALS) without a clearly identified source. We measured serum p-tau 181 and p-tau 217 in a multicentre cohort of ALS (n = 152), AD (n = 111) cases and disease controls (n = 99) recruited from four different centres. Further, we investigated the existence of both p-tau species using immunohistochemistry (IHC) and mass spectrometry (MS) in muscle biopsies of ALS cases (IHC: n = 13, MS: n = 5) and disease controls (IHC: n = 14, MS: n = 5) from one cohort. Serum p-tau 181 and p-tau 217 were higher in AD and ALS patients compared to disease controls. IHC and MS analyses revealed the presence of p-tau 181 and 217 in muscle biopsies from both ALS cases and disease controls, with ALS samples showing increased p-tau reactivity in atrophic muscle fibres. Blood p-tau species could potentially be used to diagnose both ALS and AD.

Keyword(s): Humans (MeSH) ; Amyotrophic Lateral Sclerosis: blood (MeSH) ; Amyotrophic Lateral Sclerosis: metabolism (MeSH) ; Amyotrophic Lateral Sclerosis: pathology (MeSH) ; tau Proteins: metabolism (MeSH) ; tau Proteins: blood (MeSH) ; Male (MeSH) ; Female (MeSH) ; Middle Aged (MeSH) ; Aged (MeSH) ; Phosphorylation (MeSH) ; Biomarkers: blood (MeSH) ; Alzheimer Disease: blood (MeSH) ; Alzheimer Disease: metabolism (MeSH) ; Alzheimer Disease: pathology (MeSH) ; Alzheimer Disease: diagnosis (MeSH) ; Muscle, Skeletal: metabolism (MeSH) ; Muscle, Skeletal: pathology (MeSH) ; Case-Control Studies (MeSH) ; Biopsy (MeSH) ; Aged, 80 and over (MeSH) ; Adult (MeSH) ; Cohort Studies (MeSH) ; tau Proteins ; Biomarkers ; MAPT protein, human

---

Contributing Institute(s):

1. Translational Mass Spectrometry and Biomarker Research (AG Öckl)
2. Clinical Study Center (Ulm) (Clinical Study Center (Ulm))

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2025

---

Database coverage:
; ; ; ; Article Processing Charges ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Agriculture, Biology and Environmental Sciences ; Current Contents - Life Sciences ; Current Contents - Physical, Chemical and Earth Sciences ; DOAJ Seal ; Essential Science Indicators ; Fees ; IF >= 15 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection ; Zoological Record

---