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000277429 1001_ $$aAbu-Rumeileh, Samir$$b0
000277429 245__ $$aPhosphorylated tau 181 and 217 are elevated in serum and muscle of patients with amyotrophic lateral sclerosis.
000277429 260__ $$a[London]$$bSpringer Nature$$c2025
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000277429 520__ $$aBlood phosphorylated (p)-tau 181 and p-tau 217 have been proposed as accurate biomarkers of Alzheimer's disease (AD) pathology. However, blood p-tau 181 is also elevated in amyotrophic lateral sclerosis (ALS) without a clearly identified source. We measured serum p-tau 181 and p-tau 217 in a multicentre cohort of ALS (n = 152), AD (n = 111) cases and disease controls (n = 99) recruited from four different centres. Further, we investigated the existence of both p-tau species using immunohistochemistry (IHC) and mass spectrometry (MS) in muscle biopsies of ALS cases (IHC: n = 13, MS: n = 5) and disease controls (IHC: n = 14, MS: n = 5) from one cohort. Serum p-tau 181 and p-tau 217 were higher in AD and ALS patients compared to disease controls. IHC and MS analyses revealed the presence of p-tau 181 and 217 in muscle biopsies from both ALS cases and disease controls, with ALS samples showing increased p-tau reactivity in atrophic muscle fibres. Blood p-tau species could potentially be used to diagnose both ALS and AD.
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000277429 650_7 $$2NLM Chemicals$$atau Proteins
000277429 650_7 $$2NLM Chemicals$$aBiomarkers
000277429 650_7 $$2NLM Chemicals$$aMAPT protein, human
000277429 650_2 $$2MeSH$$aHumans
000277429 650_2 $$2MeSH$$aAmyotrophic Lateral Sclerosis: blood
000277429 650_2 $$2MeSH$$aAmyotrophic Lateral Sclerosis: metabolism
000277429 650_2 $$2MeSH$$aAmyotrophic Lateral Sclerosis: pathology
000277429 650_2 $$2MeSH$$atau Proteins: metabolism
000277429 650_2 $$2MeSH$$atau Proteins: blood
000277429 650_2 $$2MeSH$$aMale
000277429 650_2 $$2MeSH$$aFemale
000277429 650_2 $$2MeSH$$aMiddle Aged
000277429 650_2 $$2MeSH$$aAged
000277429 650_2 $$2MeSH$$aPhosphorylation
000277429 650_2 $$2MeSH$$aBiomarkers: blood
000277429 650_2 $$2MeSH$$aAlzheimer Disease: blood
000277429 650_2 $$2MeSH$$aAlzheimer Disease: metabolism
000277429 650_2 $$2MeSH$$aAlzheimer Disease: pathology
000277429 650_2 $$2MeSH$$aAlzheimer Disease: diagnosis
000277429 650_2 $$2MeSH$$aMuscle, Skeletal: metabolism
000277429 650_2 $$2MeSH$$aMuscle, Skeletal: pathology
000277429 650_2 $$2MeSH$$aCase-Control Studies
000277429 650_2 $$2MeSH$$aBiopsy
000277429 650_2 $$2MeSH$$aAged, 80 and over
000277429 650_2 $$2MeSH$$aAdult
000277429 650_2 $$2MeSH$$aCohort Studies
000277429 7001_ $$aScholle, Leila$$b1
000277429 7001_ $$00000-0003-0089-4473$$aMensch, Alexander$$b2
000277429 7001_ $$00000-0002-5122-2477$$aGroßkopf, Henning$$b3
000277429 7001_ $$00000-0002-4264-6614$$aRatti, Antonia$$b4
000277429 7001_ $$aKölsch, Anna$$b5
000277429 7001_ $$aStoltenburg-Didinger, Gisela$$b6
000277429 7001_ $$aConrad, Julian$$b7
000277429 7001_ $$aDe Gobbi, Anna$$b8
000277429 7001_ $$aBarba, Lorenzo$$b9
000277429 7001_ $$aSteinacker, Petra$$b10
000277429 7001_ $$00000-0002-8672-9032$$aKlafki, Hans-Wolfgang$$b11
000277429 7001_ $$0P:(DE-2719)9001560$$aOeckl, Patrick$$b12
000277429 7001_ $$0P:(DE-2719)9002026$$aHalbgebauer, Steffen$$b13
000277429 7001_ $$aStapf, Caroline$$b14
000277429 7001_ $$aPosa, Andreas$$b15
000277429 7001_ $$aKendzierski, Thomas$$b16
000277429 7001_ $$00000-0002-7698-3854$$aSilani, Vincenzo$$b17
000277429 7001_ $$00000-0001-9009-2356$$aHausner, Lucrezia$$b18
000277429 7001_ $$00000-0001-5963-7426$$aTicozzi, Nicola$$b19
000277429 7001_ $$00000-0003-1494-0813$$aFroelich, Lutz$$b20
000277429 7001_ $$aWeishaupt, Jochen Hans$$b21
000277429 7001_ $$aVerde, Federico$$b22
000277429 7001_ $$00000-0003-4273-4267$$aOtto, Markus$$b23
000277429 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-025-57144-7$$gVol. 16, no. 1, p. 2019$$n1$$p2019$$tNature Communications$$v16$$x2041-1723$$y2025
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