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@ARTICLE{AbuRumeileh:277429,
      author       = {Abu-Rumeileh, Samir and Scholle, Leila and Mensch,
                      Alexander and Großkopf, Henning and Ratti, Antonia and
                      Kölsch, Anna and Stoltenburg-Didinger, Gisela and Conrad,
                      Julian and De Gobbi, Anna and Barba, Lorenzo and Steinacker,
                      Petra and Klafki, Hans-Wolfgang and Oeckl, Patrick and
                      Halbgebauer, Steffen and Stapf, Caroline and Posa, Andreas
                      and Kendzierski, Thomas and Silani, Vincenzo and Hausner,
                      Lucrezia and Ticozzi, Nicola and Froelich, Lutz and
                      Weishaupt, Jochen Hans and Verde, Federico and Otto, Markus},
      title        = {{P}hosphorylated tau 181 and 217 are elevated in serum and
                      muscle of patients with amyotrophic lateral sclerosis.},
      journal      = {Nature Communications},
      volume       = {16},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Springer Nature},
      reportid     = {DZNE-2025-00412},
      pages        = {2019},
      year         = {2025},
      abstract     = {Blood phosphorylated (p)-tau 181 and p-tau 217 have been
                      proposed as accurate biomarkers of Alzheimer's disease (AD)
                      pathology. However, blood p-tau 181 is also elevated in
                      amyotrophic lateral sclerosis (ALS) without a clearly
                      identified source. We measured serum p-tau 181 and p-tau 217
                      in a multicentre cohort of ALS (n = 152), AD (n = 111) cases
                      and disease controls (n = 99) recruited from four different
                      centres. Further, we investigated the existence of both
                      p-tau species using immunohistochemistry (IHC) and mass
                      spectrometry (MS) in muscle biopsies of ALS cases (IHC: n =
                      13, MS: n = 5) and disease controls (IHC: n = 14, MS: n = 5)
                      from one cohort. Serum p-tau 181 and p-tau 217 were higher
                      in AD and ALS patients compared to disease controls. IHC and
                      MS analyses revealed the presence of p-tau 181 and 217 in
                      muscle biopsies from both ALS cases and disease controls,
                      with ALS samples showing increased p-tau reactivity in
                      atrophic muscle fibres. Blood p-tau species could
                      potentially be used to diagnose both ALS and AD.},
      keywords     = {Humans / Amyotrophic Lateral Sclerosis: blood / Amyotrophic
                      Lateral Sclerosis: metabolism / Amyotrophic Lateral
                      Sclerosis: pathology / tau Proteins: metabolism / tau
                      Proteins: blood / Male / Female / Middle Aged / Aged /
                      Phosphorylation / Biomarkers: blood / Alzheimer Disease:
                      blood / Alzheimer Disease: metabolism / Alzheimer Disease:
                      pathology / Alzheimer Disease: diagnosis / Muscle, Skeletal:
                      metabolism / Muscle, Skeletal: pathology / Case-Control
                      Studies / Biopsy / Aged, 80 and over / Adult / Cohort
                      Studies / tau Proteins (NLM Chemicals) / Biomarkers (NLM
                      Chemicals) / MAPT protein, human (NLM Chemicals)},
      cin          = {AG Öckl / Clinical Study Center (Ulm)},
      ddc          = {500},
      cid          = {I:(DE-2719)5000073 / I:(DE-2719)5000077},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40044663},
      pmc          = {pmc:PMC11882981},
      doi          = {10.1038/s41467-025-57144-7},
      url          = {https://pub.dzne.de/record/277429},
}