Home > Publications Database > Phosphorylated tau 181 and 217 are elevated in serum and muscle of patients with amyotrophic lateral sclerosis. > print

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024 7 _ |a 10.1038/s41467-025-57144-7
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037 _ _ |a DZNE-2025-00412
041 _ _ |a English
082 _ _ |a 500
100 1 _ |a Abu-Rumeileh, Samir
|b 0
245 _ _ |a Phosphorylated tau 181 and 217 are elevated in serum and muscle of patients with amyotrophic lateral sclerosis.
260 _ _ |a [London]
|c 2025
|b Springer Nature
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520 _ _ |a Blood phosphorylated (p)-tau 181 and p-tau 217 have been proposed as accurate biomarkers of Alzheimer's disease (AD) pathology. However, blood p-tau 181 is also elevated in amyotrophic lateral sclerosis (ALS) without a clearly identified source. We measured serum p-tau 181 and p-tau 217 in a multicentre cohort of ALS (n = 152), AD (n = 111) cases and disease controls (n = 99) recruited from four different centres. Further, we investigated the existence of both p-tau species using immunohistochemistry (IHC) and mass spectrometry (MS) in muscle biopsies of ALS cases (IHC: n = 13, MS: n = 5) and disease controls (IHC: n = 14, MS: n = 5) from one cohort. Serum p-tau 181 and p-tau 217 were higher in AD and ALS patients compared to disease controls. IHC and MS analyses revealed the presence of p-tau 181 and 217 in muscle biopsies from both ALS cases and disease controls, with ALS samples showing increased p-tau reactivity in atrophic muscle fibres. Blood p-tau species could potentially be used to diagnose both ALS and AD.
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650 _ 7 |a tau Proteins
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650 _ 7 |a Biomarkers
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650 _ 7 |a MAPT protein, human
|2 NLM Chemicals
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Amyotrophic Lateral Sclerosis: blood
|2 MeSH
650 _ 2 |a Amyotrophic Lateral Sclerosis: metabolism
|2 MeSH
650 _ 2 |a Amyotrophic Lateral Sclerosis: pathology
|2 MeSH
650 _ 2 |a tau Proteins: metabolism
|2 MeSH
650 _ 2 |a tau Proteins: blood
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a Aged
|2 MeSH
650 _ 2 |a Phosphorylation
|2 MeSH
650 _ 2 |a Biomarkers: blood
|2 MeSH
650 _ 2 |a Alzheimer Disease: blood
|2 MeSH
650 _ 2 |a Alzheimer Disease: metabolism
|2 MeSH
650 _ 2 |a Alzheimer Disease: pathology
|2 MeSH
650 _ 2 |a Alzheimer Disease: diagnosis
|2 MeSH
650 _ 2 |a Muscle, Skeletal: metabolism
|2 MeSH
650 _ 2 |a Muscle, Skeletal: pathology
|2 MeSH
650 _ 2 |a Case-Control Studies
|2 MeSH
650 _ 2 |a Biopsy
|2 MeSH
650 _ 2 |a Aged, 80 and over
|2 MeSH
650 _ 2 |a Adult
|2 MeSH
650 _ 2 |a Cohort Studies
|2 MeSH
700 1 _ |a Scholle, Leila
|b 1
700 1 _ |a Mensch, Alexander
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700 1 _ |a Großkopf, Henning
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700 1 _ |a Ratti, Antonia
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700 1 _ |a Kölsch, Anna
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700 1 _ |a Stoltenburg-Didinger, Gisela
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700 1 _ |a Conrad, Julian
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700 1 _ |a De Gobbi, Anna
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700 1 _ |a Barba, Lorenzo
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700 1 _ |a Steinacker, Petra
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700 1 _ |a Klafki, Hans-Wolfgang
|0 0000-0002-8672-9032
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700 1 _ |a Oeckl, Patrick
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700 1 _ |a Halbgebauer, Steffen
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700 1 _ |a Stapf, Caroline
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700 1 _ |a Posa, Andreas
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700 1 _ |a Kendzierski, Thomas
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700 1 _ |a Silani, Vincenzo
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700 1 _ |a Hausner, Lucrezia
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700 1 _ |a Ticozzi, Nicola
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700 1 _ |a Froelich, Lutz
|0 0000-0003-1494-0813
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700 1 _ |a Weishaupt, Jochen Hans
|b 21
700 1 _ |a Verde, Federico
|b 22
700 1 _ |a Otto, Markus
|0 0000-0003-4273-4267
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773 _ _ |a 10.1038/s41467-025-57144-7
|g Vol. 16, no. 1, p. 2019
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