TY  - JOUR
AU  - Lewis, Karyn
AU  - Vallone, Valeria Fernandez
AU  - Dordevic, Adam
AU  - Kern, Johannes
AU  - Stachelscheid, Harald
AU  - Endres, Matthias
AU  - Boehmerle, Wolfgang
AU  - Huehnchen, Petra
AU  - Schinke, Christian
TI  - Generation of ten human induced pluripotent stem cell lines (hiPSCs) from patients with and without Chemotherapy-Induced Peripheral Neuropathy (CIPN) and Post Chemotherapy Cognitive Impairment (PCCI).
JO  - Stem cell research
VL  - 84
SN  - 1873-5061
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - DZNE-2025-00432
SP  - 103674 -
PY  - 2025
AB  - Chemotherapy-induced peripheral neuropathy (CIPN) and post-chemotherapy cognitive impairment (PCCI) represent major side effects of chemotherapy. Using Sendai virus vectors, ten hiPSC lines from patients who had undergone chemotherapy and did or did not develop CIPN and PCCI were generated. Each line was characterized to confirm markers of the undifferentiated state, differentiation potential, genomic integrity, identity verification and reprogramming vector removal. These lines serve as a valuable resource to create two disease models for 1) CIPN (hiPSC lines from five patients with CIPN vs. five without CIPN) and 2) PCCI (hiPSC lines from four patients with PCCI vs. five without PCCI).
KW  - Humans
KW  - Induced Pluripotent Stem Cells
KW  - Peripheral Nervous System Diseases: chemically induced
KW  - Peripheral Nervous System Diseases: pathology
KW  - Peripheral Nervous System Diseases: therapy
KW  - Cognitive Dysfunction: chemically induced
KW  - Male
KW  - Female
KW  - Cell Line
KW  - Middle Aged
KW  - Cell Differentiation
KW  - Antineoplastic Agents: adverse effects
KW  - Aged
KW  - Adult
KW  - Antineoplastic Agents (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:40015137
DO  - DOI:10.1016/j.scr.2025.103674
UR  - https://pub.dzne.de/record/277541
ER  -