Journal Article

DZNE-2025-00432

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Generation of ten human induced pluripotent stem cell lines (hiPSCs) from patients with and without Chemotherapy-Induced Peripheral Neuropathy (CIPN) and Post Chemotherapy Cognitive Impairment (PCCI).

Lewis, K. ; Vallone, V. F. ; Dordevic, A. ; Kern, J. ; Stachelscheid, H. ; Endres, M.DZNE* ; Boehmerle, W. ; Huehnchen, P. ; Schinke, C.

2025
Elsevier Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.scr.2025.103674

Abstract: Chemotherapy-induced peripheral neuropathy (CIPN) and post-chemotherapy cognitive impairment (PCCI) represent major side effects of chemotherapy. Using Sendai virus vectors, ten hiPSC lines from patients who had undergone chemotherapy and did or did not develop CIPN and PCCI were generated. Each line was characterized to confirm markers of the undifferentiated state, differentiation potential, genomic integrity, identity verification and reprogramming vector removal. These lines serve as a valuable resource to create two disease models for 1) CIPN (hiPSC lines from five patients with CIPN vs. five without CIPN) and 2) PCCI (hiPSC lines from four patients with PCCI vs. five without PCCI).

Keyword(s): Humans (MeSH) ; Induced Pluripotent Stem Cells (MeSH) ; Peripheral Nervous System Diseases: chemically induced (MeSH) ; Peripheral Nervous System Diseases: pathology (MeSH) ; Peripheral Nervous System Diseases: therapy (MeSH) ; Cognitive Dysfunction: chemically induced (MeSH) ; Male (MeSH) ; Female (MeSH) ; Cell Line (MeSH) ; Middle Aged (MeSH) ; Cell Differentiation (MeSH) ; Antineoplastic Agents: adverse effects (MeSH) ; Aged (MeSH) ; Adult (MeSH) ; Antineoplastic Agents

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Contributing Institute(s):

1. Interdisciplinary Dementia Research (AG Endres)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2025

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