Home > Publications Database > Generation of ten human induced pluripotent stem cell lines (hiPSCs) from patients with and without Chemotherapy-Induced Peripheral Neuropathy (CIPN) and Post Chemotherapy Cognitive Impairment (PCCI). > print

001     277541
005     20250323001003.0
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041 _ _ |a English
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100 1 _ |a Lewis, Karyn
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245 _ _ |a Generation of ten human induced pluripotent stem cell lines (hiPSCs) from patients with and without Chemotherapy-Induced Peripheral Neuropathy (CIPN) and Post Chemotherapy Cognitive Impairment (PCCI).
260 _ _ |a Amsterdam [u.a.]
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520 _ _ |a Chemotherapy-induced peripheral neuropathy (CIPN) and post-chemotherapy cognitive impairment (PCCI) represent major side effects of chemotherapy. Using Sendai virus vectors, ten hiPSC lines from patients who had undergone chemotherapy and did or did not develop CIPN and PCCI were generated. Each line was characterized to confirm markers of the undifferentiated state, differentiation potential, genomic integrity, identity verification and reprogramming vector removal. These lines serve as a valuable resource to create two disease models for 1) CIPN (hiPSC lines from five patients with CIPN vs. five without CIPN) and 2) PCCI (hiPSC lines from four patients with PCCI vs. five without PCCI).
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650 _ 7 |a Antineoplastic Agents
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650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Induced Pluripotent Stem Cells
|2 MeSH
650 _ 2 |a Peripheral Nervous System Diseases: chemically induced
|2 MeSH
650 _ 2 |a Peripheral Nervous System Diseases: pathology
|2 MeSH
650 _ 2 |a Peripheral Nervous System Diseases: therapy
|2 MeSH
650 _ 2 |a Cognitive Dysfunction: chemically induced
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Cell Line
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a Cell Differentiation
|2 MeSH
650 _ 2 |a Antineoplastic Agents: adverse effects
|2 MeSH
650 _ 2 |a Aged
|2 MeSH
650 _ 2 |a Adult
|2 MeSH
700 1 _ |a Vallone, Valeria Fernandez
|b 1
700 1 _ |a Dordevic, Adam
|b 2
700 1 _ |a Kern, Johannes
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700 1 _ |a Stachelscheid, Harald
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700 1 _ |a Endres, Matthias
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700 1 _ |a Boehmerle, Wolfgang
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700 1 _ |a Huehnchen, Petra
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700 1 _ |a Schinke, Christian
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773 _ _ |a 10.1016/j.scr.2025.103674
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|t Stem cell research
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