%0 Journal Article
%A Palix, Cassandre
%A Chauveau, Léa
%A Felisatti, Francesca
%A Chocat, Anne
%A Coulbault, Laurent
%A Hébert, Oriane
%A Mézenge, Florence
%A Landeau, Brigitte
%A Haudry, Sacha
%A Fauvel, Séverine
%A Collette, Fabienne
%A Klimecki, Olga
%A Marchant, Natalie L
%A De La Sayette, Vincent
%A Vivien, Denis
%A Chételat, Gaël
%A Poisnel, Géraldine
%T Allostatic load, a measure of cumulative physiological stress, impairs brain structure but not β-accumulation in older adults: an exploratory study.
%J Frontiers in aging neuroscience
%V 17
%@ 1663-4365
%C Lausanne
%I Frontiers Research Foundation
%M DZNE-2025-00529
%P 1508677
%D 2025
%X Allostatic load (AL) is a composite score of progressive physiological dysregulations in response to long-term exposure to everyday stress. Despite growing interest, limited research has focused on links with cerebral and cognitive aspects of aging and with markers sensitive to Alzheimer's disease (AD) in a healthy elderly population and with a multimodal approach.At baseline, 111 older adults (without cognitive impairment) from the Age-Well trial completed blood and anthropometric markers collection, cognitive assessments and multimodal neuroimaging within 3 months.AL was negatively associated with gray matter volume and white matter integrity within frontal and temporal regions and poorer attentional performance.AL is linked to structural brain integrity in aging- and stress-sensitive regions but not with AD-related markers (β-amyloid load) and only in two AD-sensitive brain regions in older adults. These results highlight the potential interest of AL as a sensitive index of stress-induced brain aging.
%K Alzheimer’s disease (Other)
%K aging (Other)
%K allostatic load (Other)
%K amyloid (Other)
%K brain (Other)
%K cognition (Other)
%K neuroimaging (Other)
%K stress (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:40230487
%2 pmc:PMC11994863
%R 10.3389/fnagi.2025.1508677
%U https://pub.dzne.de/record/278002