Journal Article

DZNE-2025-00529

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Allostatic load, a measure of cumulative physiological stress, impairs brain structure but not β-accumulation in older adults: an exploratory study.

Palix, C. ; Chauveau, L. ; Felisatti, F. ; Chocat, A. ; Coulbault, L. ; Hébert, O. ; Mézenge, F. ; Landeau, B. ; Haudry, S. ; Fauvel, S. ; Collette, F. ; Klimecki, O.DZNE* ; Marchant, N. L. ; De La Sayette, V. ; Vivien, D. ; Chételat, G. ; Poisnel, G. ; Group, M. R. (Collaboration Author)

2025
Frontiers Research Foundation Lausanne

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Please use a persistent id in citations: doi:10.3389/fnagi.2025.1508677

Abstract: Allostatic load (AL) is a composite score of progressive physiological dysregulations in response to long-term exposure to everyday stress. Despite growing interest, limited research has focused on links with cerebral and cognitive aspects of aging and with markers sensitive to Alzheimer's disease (AD) in a healthy elderly population and with a multimodal approach.At baseline, 111 older adults (without cognitive impairment) from the Age-Well trial completed blood and anthropometric markers collection, cognitive assessments and multimodal neuroimaging within 3 months.AL was negatively associated with gray matter volume and white matter integrity within frontal and temporal regions and poorer attentional performance.AL is linked to structural brain integrity in aging- and stress-sensitive regions but not with AD-related markers (β-amyloid load) and only in two AD-sensitive brain regions in older adults. These results highlight the potential interest of AL as a sensitive index of stress-induced brain aging.

Keyword(s): Alzheimer’s disease ; aging ; allostatic load ; amyloid ; brain ; cognition ; neuroimaging ; stress

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Contributing Institute(s):

1. Brain Resilience (AG Wirth)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2025

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