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000278002 1001_ $$aPalix, Cassandre$$b0
000278002 245__ $$aAllostatic load, a measure of cumulative physiological stress, impairs brain structure but not β-accumulation in older adults: an exploratory study.
000278002 260__ $$aLausanne$$bFrontiers Research Foundation$$c2025
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000278002 520__ $$aAllostatic load (AL) is a composite score of progressive physiological dysregulations in response to long-term exposure to everyday stress. Despite growing interest, limited research has focused on links with cerebral and cognitive aspects of aging and with markers sensitive to Alzheimer's disease (AD) in a healthy elderly population and with a multimodal approach.At baseline, 111 older adults (without cognitive impairment) from the Age-Well trial completed blood and anthropometric markers collection, cognitive assessments and multimodal neuroimaging within 3 months.AL was negatively associated with gray matter volume and white matter integrity within frontal and temporal regions and poorer attentional performance.AL is linked to structural brain integrity in aging- and stress-sensitive regions but not with AD-related markers (β-amyloid load) and only in two AD-sensitive brain regions in older adults. These results highlight the potential interest of AL as a sensitive index of stress-induced brain aging.
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000278002 650_7 $$2Other$$aAlzheimer’s disease
000278002 650_7 $$2Other$$aaging
000278002 650_7 $$2Other$$aallostatic load
000278002 650_7 $$2Other$$aamyloid
000278002 650_7 $$2Other$$abrain
000278002 650_7 $$2Other$$acognition
000278002 650_7 $$2Other$$aneuroimaging
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000278002 7001_ $$aChauveau, Léa$$b1
000278002 7001_ $$aFelisatti, Francesca$$b2
000278002 7001_ $$aChocat, Anne$$b3
000278002 7001_ $$aCoulbault, Laurent$$b4
000278002 7001_ $$aHébert, Oriane$$b5
000278002 7001_ $$aMézenge, Florence$$b6
000278002 7001_ $$aLandeau, Brigitte$$b7
000278002 7001_ $$aHaudry, Sacha$$b8
000278002 7001_ $$aFauvel, Séverine$$b9
000278002 7001_ $$aCollette, Fabienne$$b10
000278002 7001_ $$0P:(DE-2719)9002456$$aKlimecki, Olga$$b11$$udzne
000278002 7001_ $$aMarchant, Natalie L$$b12
000278002 7001_ $$aDe La Sayette, Vincent$$b13
000278002 7001_ $$aVivien, Denis$$b14
000278002 7001_ $$aChételat, Gaël$$b15
000278002 7001_ $$aPoisnel, Géraldine$$b16
000278002 7001_ $$aGroup, Medit-Ageing Research$$b17$$eCollaboration Author
000278002 773__ $$0PERI:(DE-600)2558898-9$$a10.3389/fnagi.2025.1508677$$gVol. 17, p. 1508677$$p1508677$$tFrontiers in aging neuroscience$$v17$$x1663-4365$$y2025
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