TY  - JOUR
AU  - Palix, Cassandre
AU  - Chauveau, Léa
AU  - Felisatti, Francesca
AU  - Chocat, Anne
AU  - Coulbault, Laurent
AU  - Hébert, Oriane
AU  - Mézenge, Florence
AU  - Landeau, Brigitte
AU  - Haudry, Sacha
AU  - Fauvel, Séverine
AU  - Collette, Fabienne
AU  - Klimecki, Olga
AU  - Marchant, Natalie L
AU  - De La Sayette, Vincent
AU  - Vivien, Denis
AU  - Chételat, Gaël
AU  - Poisnel, Géraldine
TI  - Allostatic load, a measure of cumulative physiological stress, impairs brain structure but not β-accumulation in older adults: an exploratory study.
JO  - Frontiers in aging neuroscience
VL  - 17
SN  - 1663-4365
CY  - Lausanne
PB  - Frontiers Research Foundation
M1  - DZNE-2025-00529
SP  - 1508677
PY  - 2025
AB  - Allostatic load (AL) is a composite score of progressive physiological dysregulations in response to long-term exposure to everyday stress. Despite growing interest, limited research has focused on links with cerebral and cognitive aspects of aging and with markers sensitive to Alzheimer's disease (AD) in a healthy elderly population and with a multimodal approach.At baseline, 111 older adults (without cognitive impairment) from the Age-Well trial completed blood and anthropometric markers collection, cognitive assessments and multimodal neuroimaging within 3 months.AL was negatively associated with gray matter volume and white matter integrity within frontal and temporal regions and poorer attentional performance.AL is linked to structural brain integrity in aging- and stress-sensitive regions but not with AD-related markers (β-amyloid load) and only in two AD-sensitive brain regions in older adults. These results highlight the potential interest of AL as a sensitive index of stress-induced brain aging.
KW  - Alzheimer’s disease (Other)
KW  - aging (Other)
KW  - allostatic load (Other)
KW  - amyloid (Other)
KW  - brain (Other)
KW  - cognition (Other)
KW  - neuroimaging (Other)
KW  - stress (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40230487
C2  - pmc:PMC11994863
DO  - DOI:10.3389/fnagi.2025.1508677
UR  - https://pub.dzne.de/record/278002
ER  -