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@ARTICLE{Palix:278002,
      author       = {Palix, Cassandre and Chauveau, Léa and Felisatti,
                      Francesca and Chocat, Anne and Coulbault, Laurent and
                      Hébert, Oriane and Mézenge, Florence and Landeau, Brigitte
                      and Haudry, Sacha and Fauvel, Séverine and Collette,
                      Fabienne and Klimecki, Olga and Marchant, Natalie L and De
                      La Sayette, Vincent and Vivien, Denis and Chételat, Gaël
                      and Poisnel, Géraldine},
      collaboration = {Group, Medit-Ageing Research},
      title        = {{A}llostatic load, a measure of cumulative physiological
                      stress, impairs brain structure but not β-accumulation in
                      older adults: an exploratory study.},
      journal      = {Frontiers in aging neuroscience},
      volume       = {17},
      issn         = {1663-4365},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {DZNE-2025-00529},
      pages        = {1508677},
      year         = {2025},
      abstract     = {Allostatic load (AL) is a composite score of progressive
                      physiological dysregulations in response to long-term
                      exposure to everyday stress. Despite growing interest,
                      limited research has focused on links with cerebral and
                      cognitive aspects of aging and with markers sensitive to
                      Alzheimer's disease (AD) in a healthy elderly population and
                      with a multimodal approach.At baseline, 111 older adults
                      (without cognitive impairment) from the Age-Well trial
                      completed blood and anthropometric markers collection,
                      cognitive assessments and multimodal neuroimaging within 3
                      months.AL was negatively associated with gray matter volume
                      and white matter integrity within frontal and temporal
                      regions and poorer attentional performance.AL is linked to
                      structural brain integrity in aging- and stress-sensitive
                      regions but not with AD-related markers (β-amyloid load)
                      and only in two AD-sensitive brain regions in older adults.
                      These results highlight the potential interest of AL as a
                      sensitive index of stress-induced brain aging.},
      keywords     = {Alzheimer’s disease (Other) / aging (Other) / allostatic
                      load (Other) / amyloid (Other) / brain (Other) / cognition
                      (Other) / neuroimaging (Other) / stress (Other)},
      cin          = {AG Wirth},
      ddc          = {610},
      cid          = {I:(DE-2719)1710011},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40230487},
      pmc          = {pmc:PMC11994863},
      doi          = {10.3389/fnagi.2025.1508677},
      url          = {https://pub.dzne.de/record/278002},
}