Home > Publications Database > Allostatic load, a measure of cumulative physiological stress, impairs brain structure but not β-accumulation in older adults: an exploratory study. > print

001     278002
005     20250504001154.0
024 7 _ |a 10.3389/fnagi.2025.1508677
|2 doi
024 7 _ |a pmid:40230487
|2 pmid
024 7 _ |a pmc:PMC11994863
|2 pmc
024 7 _ |a altmetric:175709785
|2 altmetric
037 _ _ |a DZNE-2025-00529
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Palix, Cassandre
|b 0
245 _ _ |a Allostatic load, a measure of cumulative physiological stress, impairs brain structure but not β-accumulation in older adults: an exploratory study.
260 _ _ |a Lausanne
|c 2025
|b Frontiers Research Foundation
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1744787154_10368
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a Allostatic load (AL) is a composite score of progressive physiological dysregulations in response to long-term exposure to everyday stress. Despite growing interest, limited research has focused on links with cerebral and cognitive aspects of aging and with markers sensitive to Alzheimer's disease (AD) in a healthy elderly population and with a multimodal approach.At baseline, 111 older adults (without cognitive impairment) from the Age-Well trial completed blood and anthropometric markers collection, cognitive assessments and multimodal neuroimaging within 3 months.AL was negatively associated with gray matter volume and white matter integrity within frontal and temporal regions and poorer attentional performance.AL is linked to structural brain integrity in aging- and stress-sensitive regions but not with AD-related markers (β-amyloid load) and only in two AD-sensitive brain regions in older adults. These results highlight the potential interest of AL as a sensitive index of stress-induced brain aging.
536 _ _ |a 353 - Clinical and Health Care Research (POF4-353)
|0 G:(DE-HGF)POF4-353
|c POF4-353
|f POF IV
|x 0
588 _ _ |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
650 _ 7 |a Alzheimer’s disease
|2 Other
650 _ 7 |a aging
|2 Other
650 _ 7 |a allostatic load
|2 Other
650 _ 7 |a amyloid
|2 Other
650 _ 7 |a brain
|2 Other
650 _ 7 |a cognition
|2 Other
650 _ 7 |a neuroimaging
|2 Other
650 _ 7 |a stress
|2 Other
700 1 _ |a Chauveau, Léa
|b 1
700 1 _ |a Felisatti, Francesca
|b 2
700 1 _ |a Chocat, Anne
|b 3
700 1 _ |a Coulbault, Laurent
|b 4
700 1 _ |a Hébert, Oriane
|b 5
700 1 _ |a Mézenge, Florence
|b 6
700 1 _ |a Landeau, Brigitte
|b 7
700 1 _ |a Haudry, Sacha
|b 8
700 1 _ |a Fauvel, Séverine
|b 9
700 1 _ |a Collette, Fabienne
|b 10
700 1 _ |a Klimecki, Olga
|0 P:(DE-2719)9002456
|b 11
|u dzne
700 1 _ |a Marchant, Natalie L
|b 12
700 1 _ |a De La Sayette, Vincent
|b 13
700 1 _ |a Vivien, Denis
|b 14
700 1 _ |a Chételat, Gaël
|b 15
700 1 _ |a Poisnel, Géraldine
|b 16
700 1 _ |a Group, Medit-Ageing Research
|b 17
|e Collaboration Author
773 _ _ |a 10.3389/fnagi.2025.1508677
|g Vol. 17, p. 1508677
|0 PERI:(DE-600)2558898-9
|p 1508677
|t Frontiers in aging neuroscience
|v 17
|y 2025
|x 1663-4365
856 4 _ |y OpenAccess
|u https://pub.dzne.de/record/278002/files/DZNE-2025-00529.pdf
856 4 _ |y OpenAccess
|x pdfa
|u https://pub.dzne.de/record/278002/files/DZNE-2025-00529.pdf?subformat=pdfa
909 C O |o oai:pub.dzne.de:278002
|p openaire
|p open_access
|p VDB
|p driver
|p dnbdelivery
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 11
|6 P:(DE-2719)9002456
913 1 _ |a DE-HGF
|b Gesundheit
|l Neurodegenerative Diseases
|1 G:(DE-HGF)POF4-350
|0 G:(DE-HGF)POF4-353
|3 G:(DE-HGF)POF4
|2 G:(DE-HGF)POF4-300
|4 G:(DE-HGF)POF
|v Clinical and Health Care Research
|x 0
914 1 _ |y 2025
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
|d 2024-12-16
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0160
|2 StatID
|b Essential Science Indicators
|d 2024-12-16
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1050
|2 StatID
|b BIOSIS Previews
|d 2024-12-16
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1190
|2 StatID
|b Biological Abstracts
|d 2024-12-16
915 _ _ |a Creative Commons Attribution CC BY 4.0
|0 LIC:(DE-HGF)CCBY4
|2 HGFVOC
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b FRONT AGING NEUROSCI : 2022
|d 2024-12-16
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0501
|2 StatID
|b DOAJ Seal
|d 2024-01-06T07:55:22Z
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0500
|2 StatID
|b DOAJ
|d 2024-01-06T07:55:22Z
915 _ _ |a WoS
|0 StatID:(DE-HGF)0113
|2 StatID
|b Science Citation Index Expanded
|d 2024-12-16
915 _ _ |a Fees
|0 StatID:(DE-HGF)0700
|2 StatID
|d 2024-12-16
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
|d 2024-12-16
915 _ _ |a IF < 5
|0 StatID:(DE-HGF)9900
|2 StatID
|d 2024-12-16
915 _ _ |a OpenAccess
|0 StatID:(DE-HGF)0510
|2 StatID
915 _ _ |a Peer Review
|0 StatID:(DE-HGF)0030
|2 StatID
|b DOAJ : Anonymous peer review
|d 2024-01-06T07:55:22Z
915 _ _ |a Article Processing Charges
|0 StatID:(DE-HGF)0561
|2 StatID
|d 2024-12-16
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
|d 2024-12-16
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
|d 2024-12-16
920 1 _ |0 I:(DE-2719)1710011
|k AG Wirth
|l Brain Resilience
|x 0
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a UNRESTRICTED
980 _ _ |a I:(DE-2719)1710011
980 1 _ |a FullTexts

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21