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000278041 1001_ $$aEckstein, Yasmin$$b0
000278041 245__ $$aProtocol for in vivo assessment of glucose control and insulin secretion and sensitivity in the pig.
000278041 260__ $$aCambridge, MA$$bCell Press$$c2025
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000278041 520__ $$aThe pig is a valuable animal model in diabetes research; however, standardized protocols are essential for evaluating in vivo metabolism. Here, we present a protocol for in vivo assessment of glucose control and insulin secretion and sensitivity in the pig. We describe steps for catheter implantation, testing of intravenous glucose tolerance, performance of hyperinsulinemic-euglycemic clamps (HECs) and hyperglycemic clamps (HGCs), and blood processing. We then detail procedures for analysis of plasma glucose, insulin, glucagon, and C-peptide concentrations as well as data analysis. For complete details on the use and execution of this protocol, please refer to Renner et al.1 and Renner et al.2.
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000278041 650_7 $$2Other$$aBiotechnology and bioengineering
000278041 650_7 $$2Other$$aMetabolism
000278041 650_7 $$2Other$$aModel Organisms
000278041 650_2 $$2MeSH$$aAnimals
000278041 650_2 $$2MeSH$$aSwine
000278041 650_2 $$2MeSH$$aInsulin Secretion: physiology
000278041 650_2 $$2MeSH$$aInsulin: metabolism
000278041 650_2 $$2MeSH$$aInsulin: blood
000278041 650_2 $$2MeSH$$aBlood Glucose: metabolism
000278041 650_2 $$2MeSH$$aBlood Glucose: analysis
000278041 650_2 $$2MeSH$$aGlucose Clamp Technique: methods
000278041 650_2 $$2MeSH$$aGlucagon: blood
000278041 650_2 $$2MeSH$$aC-Peptide: blood
000278041 650_2 $$2MeSH$$aGlucose Tolerance Test: methods
000278041 7001_ $$aKessler, Barbara$$b1
000278041 7001_ $$aHinrichs, Arne$$b2
000278041 7001_ $$aNovak, Istvan$$b3
000278041 7001_ $$0P:(DE-2719)9000925$$avon Thaden, Anne$$b4$$udzne
000278041 7001_ $$aLorenzen, Timo$$b5
000278041 7001_ $$aRathkolb, Birgit$$b6
000278041 7001_ $$aScholz, Armin$$b7
000278041 7001_ $$aBlutke, Andreas$$b8
000278041 7001_ $$aKoopmans, Sietse-Jan$$b9
000278041 7001_ $$ade Angelis, Martin Hrabĕ$$b10
000278041 7001_ $$aChristoffersen, Berit Østergaard$$b11
000278041 7001_ $$aWolf, Eckhard$$b12
000278041 7001_ $$aRenner, Simone$$b13
000278041 773__ $$0PERI:(DE-600)3053335-1$$a10.1016/j.xpro.2025.103774$$gVol. 6, no. 2, p. 103774 -$$n2$$p103774$$tSTAR Protocols$$v6$$x2666-1667$$y2025
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