TY  - JOUR
AU  - Loft, Anne
AU  - Emont, Margo P
AU  - Weinstock, Ada
AU  - Divoux, Adeline
AU  - Ghosh, Adhideb
AU  - Wagner, Allon
AU  - Hertzel, Ann V
AU  - Maniyadath, Babukrishna
AU  - Deplancke, Bart
AU  - Liu, Boxiang
AU  - Scheele, Camilla
AU  - Lumeng, Carey
AU  - Ding, Changhai
AU  - Ma, Chenkai
AU  - Wolfrum, Christian
AU  - Strieder-Barboza, Clarissa
AU  - Li, Congru
AU  - Truong, Danh D
AU  - Bernlohr, David A
AU  - Stener-Victorin, Elisabet
AU  - Kershaw, Erin E
AU  - Yeger-Lotem, Esti
AU  - Shamsi, Farnaz
AU  - Hui, Hannah X
AU  - Camara, Henrique
AU  - Zhong, Jiawei
AU  - Kalucka, Joanna
AU  - Ludwig, Joseph A
AU  - Semon, Julie A
AU  - Jalkanen, Jutta
AU  - Whytock, Katie L
AU  - Dumont, Kyle D
AU  - Sparks, Lauren M
AU  - Muir, Lindsey A
AU  - Fang, Lingzhao
AU  - Massier, Lucas
AU  - Saraiva, Luis R
AU  - Beyer, Marc D
AU  - Jeschke, Marc G
AU  - Mori, Marcelo A
AU  - Boroni, Mariana
AU  - Walsh, Martin J
AU  - Patti, Mary-Elizabeth
AU  - Lynes, Matthew D
AU  - Blüher, Matthias
AU  - Rydén, Mikael
AU  - Hamda, Natnael
AU  - Solimini, Nicole L
AU  - Mejhert, Niklas
AU  - Gao, Peng
AU  - Gupta, Rana K
AU  - Murphy, Rinki
AU  - Pirouzpanah, Saeed
AU  - Corvera, Silvia
AU  - Tang, Su'an
AU  - Das, Swapan K
AU  - Schmidt, Søren F
AU  - Zhang, Tao
AU  - Nelson, Theodore M
AU  - O'Sullivan, Timothy E
AU  - Efthymiou, Vissarion
AU  - Wang, Wenjing
AU  - Tong, Yihan
AU  - Tseng, Yu-Hua
AU  - Mandrup, Susanne
AU  - Rosen, Evan D
TI  - Towards a consensus atlas of human and mouse adipose tissue at single-cell resolution.
JO  - Nature metabolism
VL  - 7
IS  - 5
SN  - 2522-5812
CY  - [London]
PB  - Springer Nature
M1  - DZNE-2025-00636
SP  - 875 - 894
PY  - 2025
AB  - Adipose tissue (AT) is a complex connective tissue with a high relative proportion of adipocytes, which are specialized cells with the ability to store lipids in large droplets. AT is found in multiple discrete depots throughout the body, where it serves as the primary repository for excess calories. In addition, AT has an important role in functions as diverse as insulation, immunity and regulation of metabolic homeostasis. The Human Cell Atlas Adipose Bionetwork was established to support the generation of single-cell atlases of human AT as well as the development of unified approaches and consensus for cell annotation. Here, we provide a first roadmap from this bionetwork, including our suggested cell annotations for humans and mice, with the aim of describing the state of the field and providing guidelines for the production, analysis, interpretation and presentation of AT single-cell data.
KW  - Humans
KW  - Adipose Tissue: cytology
KW  - Adipose Tissue: metabolism
KW  - Mice
KW  - Animals
KW  - Single-Cell Analysis: methods
KW  - Adipocytes: metabolism
KW  - Adipocytes: cytology
KW  - Atlases as Topic
LB  - PUB:(DE-HGF)16
C6  - pmid:40360756
DO  - DOI:10.1038/s42255-025-01296-9
UR  - https://pub.dzne.de/record/278910
ER  -