Journal Article

DZNE-2025-00636

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Towards a consensus atlas of human and mouse adipose tissue at single-cell resolution.

Loft, A. ; Emont, M. P. ; Weinstock, A. ; Divoux, A. ; Ghosh, A. ; Wagner, A. ; Hertzel, A. V. ; Maniyadath, B. ; Deplancke, B. ; Liu, B. ; Scheele, C. ; Lumeng, C. ; Ding, C. ; Ma, C. ; Wolfrum, C. ; Strieder-Barboza, C. ; Li, C. ; Truong, D. D. ; Bernlohr, D. A. ; Stener-Victorin, E. ; Kershaw, E. E. ; Yeger-Lotem, E. ; Shamsi, F. ; Hui, H. X. ; Camara, H. ; Zhong, J. ; Kalucka, J. ; Ludwig, J. A. ; Semon, J. A. ; Jalkanen, J. ; Whytock, K. L. ; Dumont, K. D. ; Sparks, L. M. ; Muir, L. A. ; Fang, L. ; Massier, L. ; Saraiva, L. R. ; Beyer, M. D.DZNE* ; Jeschke, M. G. ; Mori, M. A. ; Boroni, M. ; Walsh, M. J. ; Patti, M.-E. ; Lynes, M. D. ; Blüher, M. ; Rydén, M. ; Hamda, N. ; Solimini, N. L. ; Mejhert, N. ; Gao, P. ; Gupta, R. K. ; Murphy, R. ; Pirouzpanah, S. ; Corvera, S. ; Tang, S. ; Das, S. K. ; Schmidt, S. F. ; Zhang, T. ; Nelson, T. M. ; O'Sullivan, T. E. ; Efthymiou, V. ; Wang, W. ; Tong, Y. ; Tseng, Y.-H. ; Mandrup, S. ; Rosen, E. D.

2025
Springer Nature [London]

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Please use a persistent id in citations: doi:10.1038/s42255-025-01296-9

Abstract: Adipose tissue (AT) is a complex connective tissue with a high relative proportion of adipocytes, which are specialized cells with the ability to store lipids in large droplets. AT is found in multiple discrete depots throughout the body, where it serves as the primary repository for excess calories. In addition, AT has an important role in functions as diverse as insulation, immunity and regulation of metabolic homeostasis. The Human Cell Atlas Adipose Bionetwork was established to support the generation of single-cell atlases of human AT as well as the development of unified approaches and consensus for cell annotation. Here, we provide a first roadmap from this bionetwork, including our suggested cell annotations for humans and mice, with the aim of describing the state of the field and providing guidelines for the production, analysis, interpretation and presentation of AT single-cell data.

Keyword(s): Humans (MeSH) ; Adipose Tissue: cytology (MeSH) ; Adipose Tissue: metabolism (MeSH) ; Mice (MeSH) ; Animals (MeSH) ; Single-Cell Analysis: methods (MeSH) ; Adipocytes: metabolism (MeSH) ; Adipocytes: cytology (MeSH) ; Atlases as Topic (MeSH)

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Contributing Institute(s):

1. Immunogenomics and Neurodegeneration (AG Beyer)
2. Platform for Single Cell Genomics and Epigenomics (PRECISE)

Research Program(s):

1. 351 - Brain Function (POF4-351) (POF4-351)
2. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Experiment(s):

1. Platform for Single Cell Genomics and Epigenomics at DZNE University of Bonn

Appears in the scientific report 2025

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Nature ; Essential Science Indicators ; IF >= 20 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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