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005     20250604100731.0
024 7 _ |a 10.1038/s42255-025-01296-9
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037 _ _ |a DZNE-2025-00636
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Loft, Anne
|0 0000-0002-5647-8295
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245 _ _ |a Towards a consensus atlas of human and mouse adipose tissue at single-cell resolution.
260 _ _ |a [London]
|c 2025
|b Springer Nature
336 7 _ |a article
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520 _ _ |a Adipose tissue (AT) is a complex connective tissue with a high relative proportion of adipocytes, which are specialized cells with the ability to store lipids in large droplets. AT is found in multiple discrete depots throughout the body, where it serves as the primary repository for excess calories. In addition, AT has an important role in functions as diverse as insulation, immunity and regulation of metabolic homeostasis. The Human Cell Atlas Adipose Bionetwork was established to support the generation of single-cell atlases of human AT as well as the development of unified approaches and consensus for cell annotation. Here, we provide a first roadmap from this bionetwork, including our suggested cell annotations for humans and mice, with the aim of describing the state of the field and providing guidelines for the production, analysis, interpretation and presentation of AT single-cell data.
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650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Adipose Tissue: cytology
|2 MeSH
650 _ 2 |a Adipose Tissue: metabolism
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Single-Cell Analysis: methods
|2 MeSH
650 _ 2 |a Adipocytes: metabolism
|2 MeSH
650 _ 2 |a Adipocytes: cytology
|2 MeSH
650 _ 2 |a Atlases as Topic
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700 1 _ |a Emont, Margo P
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700 1 _ |a Weinstock, Ada
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700 1 _ |a Divoux, Adeline
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700 1 _ |a Ghosh, Adhideb
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700 1 _ |a Wagner, Allon
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700 1 _ |a Hertzel, Ann V
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700 1 _ |a Jalkanen, Jutta
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700 1 _ |a Dumont, Kyle D
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700 1 _ |a Sparks, Lauren M
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700 1 _ |a Muir, Lindsey A
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700 1 _ |a Fang, Lingzhao
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700 1 _ |a Massier, Lucas
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700 1 _ |a Saraiva, Luis R
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700 1 _ |a Beyer, Marc D
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700 1 _ |a Jeschke, Marc G
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700 1 _ |a Mori, Marcelo A
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700 1 _ |a Boroni, Mariana
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700 1 _ |a Walsh, Martin J
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700 1 _ |a Patti, Mary-Elizabeth
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700 1 _ |a Lynes, Matthew D
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700 1 _ |a Blüher, Matthias
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700 1 _ |a Rydén, Mikael
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700 1 _ |a Hamda, Natnael
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700 1 _ |a Solimini, Nicole L
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700 1 _ |a Mejhert, Niklas
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700 1 _ |a Gao, Peng
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700 1 _ |a Gupta, Rana K
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700 1 _ |a Murphy, Rinki
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700 1 _ |a Das, Swapan K
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700 1 _ |a Schmidt, Søren F
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700 1 _ |a Zhang, Tao
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700 1 _ |a Nelson, Theodore M
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700 1 _ |a O'Sullivan, Timothy E
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700 1 _ |a Efthymiou, Vissarion
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700 1 _ |a Wang, Wenjing
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700 1 _ |a Tong, Yihan
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700 1 _ |a Tseng, Yu-Hua
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700 1 _ |a Mandrup, Susanne
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700 1 _ |a Rosen, Evan D
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773 _ _ |a 10.1038/s42255-025-01296-9
|g Vol. 7, no. 5, p. 875 - 894
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|t Nature metabolism
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|y 2025
|x 2522-5812
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