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000278924 0247_ $$2doi$$a10.1016/j.seizure.2024.05.019
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000278924 037__ $$aDZNE-2025-00650
000278924 041__ $$aEnglish
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000278924 1001_ $$aHansen, Niels$$b0
000278924 245__ $$aFluid biomarkers unveil signatures of pathological aging.
000278924 260__ $$aOxford [u.a.]$$bElsevier$$c2025
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000278924 520__ $$aAging is a multifaceted and highly varied process in the brain. Identifying aging biomarkers is one means of distinguishing pathological from physiological aging. The aim of this narrative review is to focus on two new developments in the field of fluid biomarkers and draw attention to this excellent tool for the early detection of potential brain pathologies that delay, alter, or enable physiological aging to become pathological. Pathological aging can lower the threshold for the development of specific diseases such as late-onset epilepsy. Fluid biomarkers can reveal pathological levels at an early stage and thus indicate disease processes in the brain that begin before symptoms develop; they thus differ from physiological aging.
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000278924 650_7 $$2Other$$aBlood biomarkers
000278924 650_7 $$2Other$$aFluid biomarkers
000278924 650_7 $$2Other$$aInflammaging
000278924 650_7 $$2Other$$aLate-onset epilepsy
000278924 650_7 $$2Other$$aNeural autoantibodies
000278924 650_7 $$2Other$$aPathological and physiological aging
000278924 650_7 $$2NLM Chemicals$$aBiomarkers
000278924 650_2 $$2MeSH$$aHumans
000278924 650_2 $$2MeSH$$aBiomarkers: cerebrospinal fluid
000278924 650_2 $$2MeSH$$aAging: pathology
000278924 650_2 $$2MeSH$$aAging: cerebrospinal fluid
000278924 650_2 $$2MeSH$$aEpilepsy: cerebrospinal fluid
000278924 650_2 $$2MeSH$$aBrain: pathology
000278924 7001_ $$0P:(DE-2719)2811317$$aWiltfang, Jens$$b1$$eLast author$$udzne
000278924 773__ $$0PERI:(DE-600)2002585-3$$a10.1016/j.seizure.2024.05.019$$gVol. 128, p. 24 - 28$$p24 - 28$$tSeizure$$v128$$x1059-1311$$y2025
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